Cicada-inspired cell-instructive nanopatterned arrays.

Cicada-inspired cell-instructive nanopatterned arrays.
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DOI:
10.1038/srep07122
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发表时间:
2014-11-20
期刊:
影响因子:
4.6
通讯作者:
Ryadnov MG
Ryadnov MG
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Diu T;Faruqui N;Sjöström T;Lamarre B;Jenkinson HF;Su B;Ryadnov MG

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生物相容性表面是各种生物医学问题的关键,这些问题与宿主组织细胞整合和细菌定植之间的竞争直接相关。细胞对这种表面上的物理信号作出独特反应的能力,从而促使人们寻找对细胞有指导作用的纳米尺度模式,这是解决这一问题的一个可行办法。在这里,我们介绍了一个通用的原理工程到生物相容性,钛,底物分化细胞反应。其原理是受到蝉翅表面显示杀菌纳米柱图案的启发。在本研究中设计的表面是二氧化钛(TiO2)纳米线阵列,它对运动细菌有选择性杀菌作用,同时能够根据阵列的类型引导哺乳动物细胞增殖。这个概念为临床相关材料提供了希望,这些材料能够对细胞粘附做出不同的物理-机械反应。
Biocompatible surfaces hold key to a variety of biomedical problems that are directly related to the competition between host-tissue cell integration and bacterial colonisation. A saving solution to this is seen in the ability of cells to uniquely respond to physical cues on such surfaces thus prompting the search for cell-instructive nanoscale patterns. Here we introduce a generic rationale engineered into biocompatible, titanium, substrates to differentiate cell responses. The rationale is inspired by cicada wing surfaces that display bactericidal nanopillar patterns. The surfaces engineered in this study are titania (TiO2) nanowire arrays that are selectively bactericidal against motile bacteria, while capable of guiding mammalian cell proliferation according to the type of the array. The concept holds promise for clinically relevant materials capable of differential physico-mechanical responses to cellular adhesion.
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