Organization of the macaque monkey inferior parietal lobule based on multimodal receptor architectonics.
Organization of the macaque monkey inferior parietal lobule based on multimodal receptor architectonics.
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DOI：
10.1016/j.neuroimage.2021.117843
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发表时间：
2021-05-01
期刊：
影响因子：
5.7
通讯作者：
Palomero-Gallagher N
中科院分区：
文献类型：
--
作者：
Niu M;Rapan L;Funck T;Froudist-Walsh S;Zhao L;Zilles K;Palomero-Gallagher N
猕猴顶叶下叶（IPL）是一个结构异质的大脑区域，虽然它包含的区域数量和确定的细分的解剖/功能关系仍然存在争议。神经递质受体的分布模式不仅揭示了皮质边界的位置，而且还分离了与不同功能系统相关的区域。因此，我们进行了多模式定量分析的猕猴IPL的细胞和受体结构，以确定它所涵盖的不同领域的数量和程度。我们确定了四个地区的IPL凸性安排在尾-嘴序列，以及两个地区的顶骨盖，我们预计到Yerkes 19表面。我们发现，吻侧区有相对较小的受体指纹比尾侧的，这是在以前的研究中所描述的功能梯度沿尾-吻侧轴沿着。分层分析将IPL区域分为两个簇：尾侧簇，包含参与多感觉整合和视觉运动功能的区域，和喙侧簇，包括运动规划和动作相关功能期间活跃的区域。本研究的结果提供了新的见解澄清人类和猕猴IPL区域之间的同源性。随后的猕猴IPL的3D地图和受体指纹通过人脑项目和BALSA存储库公开提供给神经科学界，用于未来非人类灵长类动物功能成像研究的细胞和/或受体结构驱动分析。
The macaque monkey inferior parietal lobe (IPL) is a structurally heterogeneous brain region, although the number of areas it contains and the anatomical/functional relationship of identified subdivisions remains controversial. Neurotransmitter receptor distribution patterns not only reveal the position of the cortical borders, but also segregate areas associated to different functional systems. Thus we carried out a multimodal quantitative analysis of the cyto- and receptor architecture of the macaque IPL to determine the number and extent of distinct areas it encompasses. We identified four areas on the IPL convexity arranged in a caudo-rostral sequence, as well as two areas in the parietal operculum, which we projected onto the Yerkes19 surface. We found rostral areas to have relatively smaller receptor fingerprints than the caudal ones, which is in an agreement with the functional gradient along the caudo-rostral axis described in previous studies. The hierarchical analysis segregated IPL areas into two clusters: the caudal one, contains areas involved in multisensory integration and visual-motor functions, and rostral cluster, encompasses areas active during motor planning and action-related functions. The results of the present study provide novel insights into clarifying the homologies between human and macaque IPL areas. The ensuing 3D map of the macaque IPL, and the receptor fingerprints are made publicly available to the neuroscientific community via the Human Brain Project and BALSA repositories for future cyto- and/or receptor architectonically driven analyses of functional imaging studies in non-human primates.
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DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
16.2
作者：
Andersen RA;Andersen KN;Hwang EJ;Hauschild M
通讯作者：
Hauschild M
影响因子：
2.5
作者：
BARASH, S;BRACEWELL, RM;ANDERSEN, RA
通讯作者：
ANDERSEN, RA
影响因子：
2.5
作者：
BLATT, GJ;ANDERSEN, RA;STONER, GR
通讯作者：
STONER, GR
影响因子：
5.7
作者：
Caspers S;Eickhoff SB;Rick T;von Kapri A;Kuhlen T;Huang R;Shah NJ;Zilles K
通讯作者：
Zilles K