Probabilistic fibre tract analysis of cytoarchitectonically defined human inferior parietal lobule areas reveals similarities to macaques.
Probabilistic fibre tract analysis of cytoarchitectonically defined human inferior parietal lobule areas reveals similarities to macaques.
复制标题
DOI：
10.1016/j.neuroimage.2011.06.027
复制
发表时间：
2011-09-15
期刊：
影响因子：
5.7
通讯作者：
Zilles K
中科院分区：
文献类型：
--
作者：
Caspers S;Eickhoff SB;Rick T;von Kapri A;Kuhlen T;Huang R;Shah NJ;Zilles K
人类顶下小叶 (IPL) 是一个多模式大脑区域，细分为多个细胞结构区域，这些区域涉及与空间注意力、语言和高级运动处理相关的神经网络。对猕猴的示踪研究揭示了 IPL 区域的差异连接模式作为各自的结构基础。缺乏人类 IPL 的可比较差异纤维束的证据。在这里，使用概率纤维束成像研究了 5 个细胞结构人类 IPL 区域与 64 个皮质目标的解剖连接性。通过根据从种子到与目标相同距离的体素的迹线分布来评估种子和目标之间的迹线数量来评估连接可能性。主要纤维束模式逐渐从喙侧IPL转变为尾侧IPL：喙侧区域主要与体感和上顶叶区域连接，而尾侧区域与听觉、前颞叶和高级视觉皮质连接更紧密。所有 IPL 区域均与额下区、岛叶区和颞后区紧密相连。这些结果显示出与猕猴的连接模式惊人的相似性，为这两个物种之间可能的同源性提供了进一步的证据。纤维束模式的这种转变支持了嘴侧（高级运动功能）和尾侧 IPL（空间注意力）的不同功能参与，可能存在重叠的语言参与。 IPL 区域的不同功能参与得到半球不对称连接模式的进一步支持，该连接模式显示出左右差异，特别是在与感觉运动、额下和颞区的连接方面。
The human inferior parietal lobule (IPL) is a multimodal brain region, subdivided in several cytoarchitectonic areas which are involved in neural networks related to spatial attention, language, and higher motor processing. Tracer studies in macaques revealed differential connectivity patterns of IPL areas as the respective structural basis. Evidence for comparable differential fibre tracts of human IPL is lacking. Here, anatomical connectivity of five cytoarchitectonic human IPL areas to 64 cortical targets was investigated using probabilistic tractography. Connection likelihood was assessed by evaluating the number of traces between seed and target against the distribution of traces from that seed to voxels in the same distance as the target. The main fibre tract pattern shifted gradually from rostral to caudal IPL: Rostral areas were predominantly connected to somatosensory and superior parietal areas while caudal areas more strongly connected with auditory, anterior temporal and higher visual cortices. All IPL areas were strongly connected with inferior frontal, insular and posterior temporal areas. These results showed striking similarities with connectivity patterns in macaques, providing further evidence for possible homologies between these two species. This shift in fibre tract pattern supports a differential functional involvement of rostral (higher motor functions) and caudal IPL (spatial attention), with probable overlapping language involvement. The differential functional involvement of IPL areas was further supported by hemispheric asymmetries of connection patterns which showed left–right differences especially with regard to connections to sensorimotor, inferior frontal and temporal areas.
登录
查看更多内容
影响因子：
5.3
作者：
Croxson, PL;Johansen-Berg, H;Rushworth, MFS
通讯作者：
Rushworth, MFS
影响因子：
3.4
作者：
Dronkers, NF;Wilkins, DP;Jaeger, JJ
通讯作者：
Jaeger, JJ
影响因子：
3.1
作者：
Caspers, Svenja;Eickhoff, Simon B.;Amunts, Katrin
通讯作者：
Amunts, Katrin
DOI：
10.1073/pnas.0935845100
发表时间：
2003-04-29
影响因子：
11.1
作者：
Carr, L;Iacoboni, M;Lenzi, GL
通讯作者：
Lenzi, GL
影响因子：
5.7
作者：
Caspers S;Zilles K;Laird AR;Eickhoff SB
通讯作者：
Eickhoff SB