Normal and abnormal coding of somatosensory stimuli causing pain.
Normal and abnormal coding of somatosensory stimuli causing pain.
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DOI：
10.1038/nn.3629
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发表时间：
2014-02
影响因子：
25
通讯作者：
De Koninck, Yves
中科院分区：
文献类型：
--
作者：
Prescott, Steven A.;Ma, Qiufu;De Koninck, Yves
伤害性刺激引起疼痛，而疼痛通常是由伤害性刺激引起的。对这些显而易见的真理的理解是临床上重要问题的基础，并为疼痛的神经编码提供了有价值的见解。在这个视角中，我们将讨论痛苦的感觉是如何编码的。我们认为，虽然初级体感传入是专门的（即调整到特定的刺激功能），自然刺激往往激活>1类型的传入。操纵共激活模式可以改变感知，这反对每种类型的传入独立作用（正如严格标记的线条所预期的那样），而是建议不同类型的传入所传递的信号相互作用。解读介导这些相互作用的中央回路对于解释最终被感知为疼痛的神经信号的产生和调制至关重要。遗传和光学解剖技术的出现有望显着加速实现这一目标的进展，这将促进未来疼痛疗法的合理设计。
Noxious stimuli cause pain and pain arises from noxious stimuli… usually. Exceptions to these apparent truisms are the basis for clinically important problems and provide valuable insight into the neural code for pain. In this Perspective, we will discuss how painful sensations are encoded. We will argue that although primary somatosensory afferents are specialized (i.e. tuned to specific stimulus features), natural stimuli often activate >1 type of afferent. Manipulating co-activation patterns can alter perception, which argues against each type of afferent acting independently (as expected for strictly labeled lines) and suggests instead that signals conveyed by different types of afferents interact. Deciphering the central circuits that mediate those interactions is critical for explaining the generation and modulation of neural signals ultimately perceived as pain. The advent of genetic and optical dissection techniques promise to dramatically accelerate progress towards this goal, which will facilitate the rational design of future pain therapeutics.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.8
作者：
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通讯作者：
Friston KJ
影响因子：
13.9
作者：
Costigan M;Scholz J;Woolf CJ
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