Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures.
Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures.
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DOI：
10.1038/jp.2013.116
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发表时间：
2013-11
影响因子：
2.9
通讯作者：
Stark, A. R.
中科院分区：
文献类型：
--
作者：
Maitre, N. L.;Smolinsky, C.;Slaughter, J. C.;Stark, A. R.
比较左乙拉西坦（LEV）和苯巴比妥（PB）治疗新生儿癫痫后的神经发育。接受抗癫痫药物（AED）治疗新生儿癫痫发作的婴儿的回顾性研究。在校正年龄24个月时，评价LEV和PB累积暴露对死亡结局、脑瘫（CP）和贝利婴儿发育量表（BSID）评分的影响。分析调整了电描记癫痫发作次数和胎龄。在280例具有可比癫痫病因和头颅成像结果的婴儿中，PB暴露增加与BSID认知和运动评分恶化相关（每100 mg/kg降低8.1分和9分; p=0.01）。LEV的影响较小（每300 mg/kg LEV降低2.2和2.6分（p=0.01））。每100 mg/kg PB，CP概率增加2.3倍，与LEV增加无关。与LEV相比，PB暴露增加与更差的神经发育结局相关。对新生儿暴露于AED的结局进行前瞻性研究是必要的。
Compare neurodevelopment after levetiracetam (LEV) and phenobarbital (PB) for neonatal seizures. Retrospective study of infants who received antiepileptic drugs (AEDs) for neonatal seizures. Effect of cumulative exposure to LEV and PB on outcomes of death, cerebral palsy (CP), and Bayley Scales of Infant Development (BSID) scores were evaluated at 24 months corrected age. Analyses were adjusted for number of electrographic seizures and gestational age. In 280 infants with comparable seizure etiology and cranial imaging results, increased exposure to PB was associated with worse BSID cognitive and motor scores (8.1- and 9-point decrease per 100 mg/kg; p=0.01). The effect was less with LEV (2.2- and 2.6-point decrease per 300 mg/kg LEV (p=0.01). CP probability increased by 2.3-fold per 100 mg/kg PB and was not associated with increasing LEV. Increased exposure to PB is associated with worse neurodevelopmental outcomes than LEV. Prospective studies of outcomes of neonatal exposure to AEDs are essential.
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影响因子：
3
作者：
Cilio, Maria Roberta;Ferriero, Donna M.
通讯作者：
Ferriero, Donna M.
影响因子：
3.1
作者：
Ramantani, Georgia;Ikonomidou, Chrysanthy;Dinger, Juergen
通讯作者：
Dinger, Juergen
DOI：
10.5863/1551-6776-8.2.115
发表时间：
2003-04-01
期刊：
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
影响因子：
--
作者：
Ries, Michele
通讯作者：
Ries, Michele
影响因子：
2.5
作者：
Kilicdag, Hasan;Daghoglu, Kenan;Zorludemir, Suzan
通讯作者：
Zorludemir, Suzan
影响因子：
1.9
作者：
Abend NS;Gutierrez-Colina AM;Monk HM;Dlugos DJ;Clancy RR
通讯作者：
Clancy RR