Levetiracetam for treatment of neonatal seizures.
Levetiracetam for treatment of neonatal seizures.
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DOI：
10.1177/0883073810384263
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发表时间：
2011-04
影响因子：
1.9
通讯作者：
Clancy RR
中科院分区：
文献类型：
--
作者：
Abend NS;Gutierrez-Colina AM;Monk HM;Dlugos DJ;Clancy RR
新生儿癫痫发作往往是难治性的治疗与初始抗癫痫药物。因此，临床医生转向替代品，如左乙拉西坦，尽管缺乏关于其安全性，耐受性或新生儿人群的疗效的已发表数据。我们报告了一个回顾性确定的队列，其中包括23名接受左乙拉西坦治疗的经脑电图证实癫痫发作的新生儿。如果给药后24小时内癫痫发作减少50%以上，则认为左乙拉西坦有效。左乙拉西坦开始于平均受孕年龄41周。平均初始剂量为16 ± 6 mg/kg，平均最大剂量为45 ± 19 mg/kg/天。未报告或检测到呼吸或心血管不良反应。左乙拉西坦与35%（8/23）的癫痫发作减少超过50%相关，包括7例癫痫发作终止。进一步的研究是必要的，以确定最佳的左乙拉西坦剂量在新生儿和比较疗效与其他抗癫痫药物。
Neonatal seizures are often refractory to treatment with initial antiseizure medications. Consequently, clinicians turn to alternatives such as levetiracetam, despite the lack of published data regarding its safety, tolerability, or efficacy in the neonatal population. We report a retrospectively identified cohort of 23 neonates with electroencephalographically confirmed seizures who received levetiracetam. Levetiracetam was considered effective if administration was associated with a greater than 50% seizure reduction within 24 hours. Levetiracetam was initiated at a mean conceptional age of 41 weeks. The mean initial dose was 16 ± 6 mg/kg and the mean maximum dose was 45 ± 19 mg/kg/day. No respiratory or cardiovascular adverse effects were reported or detected. Levetiracetam was associated with a greater than 50% seizure reduction in 35% (8 of 23), including seizure termination in 7. Further study is warranted to determine optimal levetiracetam dosing in neonates and to compare efficacy with other antiseizure medications.
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影响因子：
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作者：
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