Persistence of Anti-SARS-CoV-2 Antibodies Depends on the Analytical Kit: A Report for Up to 10 Months after Infection.
Persistence of Anti-SARS-CoV-2 Antibodies Depends on the Analytical Kit: A Report for Up to 10 Months after Infection.
复制标题
抗SARS-COV-2抗体的持久性取决于分析试剂盒：感染后长达10个月的报告。
DOI：
10.3390/microorganisms9030556
复制
发表时间：
2021-03-08
期刊：
影响因子：
4.5
通讯作者：
Douxfils J
中科院分区：
文献类型：
--
作者：
Favresse J;Eucher C;Elsen M;Gillot C;Van Eeckhoudt S;Dogné JM;Douxfils J
几项研究已经描述了抗SARS-CoV-2抗体的长期动力学，但长期随访数据，即，>6个月，仍然稀疏。此外，文献中关于血清学应答的减弱效应不一致。本研究旨在探讨10个月内住院和非住院症状患者感染SARS-CoV-2后免疫应答的时间动态变化。使用了6种不同的SARS-CoV-2抗体检测试剂盒。确定阳性率、试验间一致性和动力学模型。观察到较高的个体间和方法间变异性。与针对IgG的检测相比，针对总抗体的检测呈现出更高的阳性率，并且更快地达到最高阳性率。这些试验之间的试验间一致性也较高。按疾病严重程度分层显示，在所有检测中，住院患者与非住院患者的血清学应答均显著升高。在这项为期10个月的随访研究中，血清学检测在检测既往SARS-CoV-2感染方面显示出临床显著差异，总抗体检测呈现出最高的阳性率。应谨慎解释几项研究中报告的减弱效应，因为它可能取决于所考虑的测定。
Several studies have described the long-term kinetics of anti-SARS-CoV-2 antibodies but long-term follow-up data, i.e., >6 months, are still sparse. Additionally, the literature is inconsistent regarding the waning effect of the serological response. The aim of this study was to explore the temporal dynamic changes of the immune response after SARS-CoV-2 infection in hospitalized and non-hospitalized symptomatic patients over a period of 10 months. Six different analytical kits for SARS-CoV-2 antibody detection were used. Positivity rates, inter-assay agreement and kinetic models were determined. A high inter-individual and an inter-methodology variability was observed. Assays targeting total antibodies presented higher positivity rates and reached the highest positivity rates sooner compared with assays directed against IgG. The inter-assay agreement was also higher between these assays. The stratification by disease severity showed a much-elevated serological response in hospitalized versus non-hospitalized patients in all assays. In this 10-month follow-up study, serological assays showed a clinically significant difference to detect past SARS-CoV-2 infection with total antibody assays presenting the highest positivity rates. The waning effect reported in several studies should be interpreted with caution because it could depend on the assay considered.
登录
查看更多内容
影响因子：
12.4
作者：
Brigger D;Horn MP;Pennington LF;Powell AE;Siegrist D;Weber B;Engler O;Piezzi V;Damonti L;Iseli P;Hauser C;Froehlich TK;Villiger PM;Bachmann MF;Leib SL;Bittel P;Fiedler M;Largiadèr CR;Marschall J;Stalder H;Kim PS;Jardetzky TS;Eggel A;Nagler M
通讯作者：
Nagler M
影响因子：
5.4
作者：
Figueiredo-Campos P;Blankenhaus B;Mota C;Gomes A;Serrano M;Ariotti S;Costa C;Nunes-Cabaço H;Mendes AM;Gaspar P;Pereira-Santos MC;Rodrigues F;Condeço J;Escoval MA;Santos M;Ramirez M;Melo-Cristino J;Simas JP;Vasconcelos E;Afonso Â;Veldhoen M
通讯作者：
Veldhoen M
DOI：
10.1016/s1473-3099(20)30943-9
发表时间：
2021-03
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Duysburgh E;Mortgat L;Barbezange C;Dierick K;Fischer N;Heyndrickx L;Hutse V;Thomas I;Van Gucht S;Vuylsteke B;Ariën KK;Desombere I
通讯作者：
Desombere I
影响因子：
24.8
作者：
Isho B;Abe KT;Zuo M;Jamal AJ;Rathod B;Wang JH;Li Z;Chao G;Rojas OL;Bang YM;Pu A;Christie-Holmes N;Gervais C;Ceccarelli D;Samavarchi-Tehrani P;Guvenc F;Budylowski P;Li A;Paterson A;Yue FY;Marin LM;Caldwell L;Wrana JL;Colwill K;Sicheri F;Mubareka S;Gray-Owen SD;Drews SJ;Siqueira WL;Barrios-Rodiles M;Ostrowski M;Rini JM;Durocher Y;McGeer AJ;Gommerman JL;Gingras AC
通讯作者：
Gingras AC
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group