Triglyceride Glucose Index Is More Closely Related to Hyperuricemia Than Obesity Indices in the Medical Checkup Population in Xinjiang, China.
Triglyceride Glucose Index Is More Closely Related to Hyperuricemia Than Obesity Indices in the Medical Checkup Population in Xinjiang, China.
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新疆体检人群甘油三酯葡萄糖指数与高尿酸血症的相关性高于肥胖指数
DOI：
10.3389/fendo.2022.861760
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发表时间：
2022
影响因子：
5.2
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Kahaer M;Zhang B;Chen W;Liang M;He Y;Chen M;Li R;Tian T;Hu C;Sun Y
高尿酸血症（HUA）是一种发病率增加的代谢异常，造成全球医疗负担。多项研究已证实肥胖和胰岛素抵抗 (IR) 是 HUA 的危险因素。关于不同肥胖指数对 HUA 的预测能力的报告有限。本研究旨在比较不同的全身肥胖、腹部肥胖和内脏肥胖指数以及 IR-甘油三酯葡萄糖 (TyG) 指数与血清尿酸 (SUA) 标记物之间的关联，并评估这些指数预测 HUA 的能力。新疆巴里坤县医院及周边乡镇卫生院共招募2243名参与者。肥胖指数包括血浆动脉粥样硬化指数、心脏代谢指数、内脏肥胖指数、脂质堆积产物指数、体型指数、体圆度指数、腰围、腰高比、体重指数和TyG指数，分为四个四分位数。此外，使用偏相关和逻辑回归分析这些指标与SUA之间的关联。采用曲线下面积（AUC）和受试者工作特征曲线来分析这些指标对 HUA 的预测价值。控制混杂变量后，无论男性还是女性，TyG 指数与 HUA 之间的关联均强于肥胖指数之间的关联。 TyG 指数最高四分位数中 HUA 的比值比 (OR)，男性为 2.098（95% 置信区间，1.555–2.831），女性为 7.788（95% CI，3.581–16.937）。对于男性，AIP、CMI、VAI、LAP 指数和 TyG 指数能够区分 HUA，其中 TyG 指数的 AUC 值最高，为 0.586（95% CI，0.557–0.614；P < 0.001）。对于女性来说，除了BMI之外的所有指标都可以区分HUA。此外，内脏肥胖指数CMI的AUC值最高，为0.737（95% CI，0.691-0.782；P < 0.001）。同时，TyG指数的AUC值相对较高，为0.728（95% CI，0.682-0.773；P < 0.001）。在中国新疆体检人群中，TyG指数与HUA显着相关，并且在识别HUA方面优于肥胖指数。
Hyperuricemia (HUA) is a metabolic anomaly with an increased incidence rate, causing a global medical burden. Several studies have confirmed that obesity and insulin resistance (IR) are the risk factors for HUA. Reports on the predictive power of different obesity indices for HUA are limited. This study aimed to compare the association between different general, abdominal, and visceral obesity indices and markers of the IR-triglyceride glucose (TyG) index with serum uric acid (SUA) and to assess the ability of these indices to predict HUA. A total of 2243 participants were recruited from Barkol County Hospital and surrounding township hospitals in Xinjiang. Obesity indices, including the atherogenic index of plasma, cardiometabolic index, visceral adiposity index, lipid accumulation product index, a body shape index, body roundness index, waist circumference, waist-to-height ratio, body mass index, and TyG index, were divided into four quartiles. Moreover, partial correlations and logistic regression were used to analyze the association between these indices and SUA. The area under the curve (AUC) and receiver operating characteristic curves were used to analyze the predictive value of these indices for HUA. After controlling for confounding variables, the association between the TyG index and HUA was stronger than that between the obesity indices in both males and females. The odds ratios (ORs) for HUA in the highest quartile of the TyG index were 2.098 (95% confidence interval, 1.555–2.831) in males and 7.788 (95% CI, 3.581–16.937) in females. For males, the AIP, CMI, VAI, LAP index, and TyG index were able to discriminate HUA, and the TyG index showed the highest AUC value of 0.586 (95% CI, 0.557–0.614; P < 0.001). For females, all indices, except BMI, can discriminate HUA. Moreover, the visceral obesity index CMI showed the highest AUC value of 0.737 (95% CI, 0.691–0.782; P < 0.001). Meanwhile, the TyG index had a relatively high AUC value of 0.728 (95% CI, 0.682–0.773; P < 0.001). The TyG index was significantly related to HUA and was superior to obesity indices in identifying HUA in the medical checkup population in Xinjiang, China.
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DOI：
10.1080/08998280.2020.1799479
发表时间：
2020-08-21
期刊：
Proceedings (Baylor University. Medical Center)
影响因子：
--
作者：
Kammar-Garcia, Ashuin;Lopez-Moreno, Patricia;Martinez-Montano, Maria de Lurdez Consuelo
通讯作者：
Martinez-Montano, Maria de Lurdez Consuelo
DOI：
10.3760/cma.j.cn112138-20200505-00449
发表时间：
2020-07-01
期刊：
Zhonghua nei ke za zhi
影响因子：
--
作者：
Huang, Y F;Yang, K H;Gu, J R
通讯作者：
Gu, J R
影响因子：
6.9
作者：
Chaudry, Oliver;Grimm, Alexandra;Engelke, Klaus
通讯作者：
Engelke, Klaus
影响因子：
16.2
作者：
Amato MC;Giordano C;Galia M;Criscimanna A;Vitabile S;Midiri M;Galluzzo A;AlkaMeSy Study Group
通讯作者：
AlkaMeSy Study Group
影响因子：
1.8
作者：
Adachi SI;Yoshizawa F;Yagasaki K
通讯作者：
Yagasaki K