Motor control and aging: links to age-related brain structural, functional, and biochemical effects.
Motor control and aging: links to age-related brain structural, functional, and biochemical effects.
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DOI：
10.1016/j.neubiorev.2009.10.005
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发表时间：
2010-04
影响因子：
8.2
通讯作者：
Lipps, David B.
中科院分区：
文献类型：
--
作者：
Seidler, Rachael D.;Bernard, Jessica A.;Burutolu, Taritonye B.;Fling, Brett W.;Gordon, Mark T.;Gwin, Joseph T.;Kwak, Youngbin;Lipps, David B.
尽管认知缺陷与年龄相关的大脑差异之间的联系已得到阐明，但与运动表现的关系却不太为人所了解。在此，除了认知 - 行动理论外，我们广泛综述了老年人中与年龄相关的大脑差异和运动缺陷。运动皮质区域和胼胝体的年龄相关性萎缩可能导致或与运动能力下降同时发生，比如平衡和步态缺陷、协调缺陷以及运动迟缓。相应地，神经递质系统（主要是多巴胺能系统）的退化可能导致与年龄相关的粗大和精细运动能力下降，以及更高层次的认知缺陷。一般来说，老年人在运动控制方面比年轻人涉及更广泛的大脑区域，尤其是前额叶皮质和基底神经节网络。不幸的是，这些相同区域最容易受到年龄相关影响，导致“供需”失衡。现有的运动、药物和运动训练干预措施可能改善老年人的运动缺陷。
Although connections between cognitive deficits and age-associated brain differences have been elucidated, relationships with motor performance are less well understood. Here, we broadly review age-related brain differences and motor deficits in older adults in addition to cognition-action theories. Age-related atrophy of the motor cortical regions and corpus callosum may precipitate or coincide with motor declines such as balance and gait deficits, coordination deficits, and movement slowing. Correspondingly, degeneration of neurotransmitter systems—primarily the dopaminergic system—may contribute to age-related gross and fine motor declines, as well as to higher cognitive deficits. In general, older adults exhibit involvement of more widespread brain regions for motor control than young adults, particularly the prefrontal cortex and basal ganglia networks. Unfortunately these same regions are the most vulnerable to age-related effects, resulting in an imbalance of “supply and demand”. Existing exercise, pharmaceutical, and motor training interventions may ameliorate motor deficits in older adults.
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影响因子：
3.3
作者：
CARLSSON, A;WINBLAD, B
通讯作者：
WINBLAD, B
DOI：
10.1093/gerona/51a.3.m116
发表时间：
1996-05-01
影响因子：
5.1
作者：
Chen, HC;Schultz, AB;Guire, KE
通讯作者：
Guire, KE
影响因子：
5.3
作者：
Boyke, Janina;Driemeyer, Joenna;May, Arne
通讯作者：
May, Arne
DOI：
10.1093/gerona/56.8.m489
发表时间：
2001-08-01
影响因子：
5.1
作者：
Brauer, SG;Woollacott, M;Shumway-Cook, A
通讯作者：
Shumway-Cook, A
影响因子：
4.2
作者：
Bartzokis, G;Sultzer, D;Cummings, JL
通讯作者：
Cummings, JL