Silver-doped bioactive glass particles for in vivo bone tissue regeneration and enhanced methicillin-resistant Staphylococcus aureus (MRSA) inhibition.
Silver-doped bioactive glass particles for in vivo bone tissue regeneration and enhanced methicillin-resistant Staphylococcus aureus (MRSA) inhibition.
复制标题
DOI：
10.1016/j.msec.2020.111693
复制
发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Chatzistavrou X
中科院分区：
文献类型：
--
作者：
Pajares-Chamorro N;Wagley Y;Maduka CV;Youngstrom DW;Yeger A;Badylak SF;Hammer ND;Hankenson K;Chatzistavrou X
Infection is a significant risk factor for failed healing of bone and other tissues. We have developed a sol-gel (solution-gelation) derived bioactive glass doped with silver ions (Ag-BG), tailored to provide non-cytotoxic antibacterial activity while significantly enhancing osteoblast-lineage cell growth in vitro and bone regeneration in vivo. Our objective was to engineer a biomaterial that combats bacterial infection while maintaining the capability to promote bone growth. We observed that Ag-BG inhibits bacterial growth and potentiates the efficacy of conventional antibiotic treatment. Ag-BG microparticles enhance cell proliferation and osteogenic differentiation in human bone marrow stromal cells (hBMSC) in vitro. Moreover, in vivo tests using a calvarial defect model in mice demonstrated that Ag-BG microparticles induce bone regeneration. This novel system with dual biological and advanced antibacterial properties is a promising therapeutic for combating resistant bacteria while triggering new bone formation.
登录
查看更多内容
影响因子：
6.4
作者：
Fey PD;Endres JL;Yajjala VK;Widhelm TJ;Boissy RJ;Bose JL;Bayles KW
通讯作者：
Bayles KW
影响因子：
14
作者：
Freytes, DO;Badylak, SF;Rundell, AE
通讯作者：
Rundell, AE
影响因子：
4.9
作者：
Dibrov, P;Dzioba, J;Häse, CC
通讯作者：
Häse, CC
DOI：
10.1007/s10856-013-4968-4
发表时间：
2013-09-01
影响因子：
3.7
作者：
Gargiulo, Nicola;Cusano, Angela Maria;Netti, Paolo Antonio
通讯作者：
Netti, Paolo Antonio
DOI：
10.1155/mbd.1994.467
发表时间：
1994
期刊：
Metal-based drugs
影响因子：
--
作者：
Clement JL;Jarrett PS
通讯作者：
Jarrett PS