A meta-analysis of effects of 3-nitrooxypropanol on methane production, yield, and intensity in dairy cattle.
A meta-analysis of effects of 3-nitrooxypropanol on methane production, yield, and intensity in dairy cattle.
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DOI：
10.3168/jds.2022-22211
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发表时间：
2023-02
影响因子：
3.5
通讯作者：
Dijkstra J
中科院分区：
文献类型：
--
作者：
Kebreab E;Bannink A;Pressman EM;Walker N;Karagiannis A;van Gastelen S;Dijkstra J
反刍动物，特别是奶牛和肉牛，主要通过肠道甲烷排放造成气候变化。已经提出了几种缓解方案，包括饲料添加剂3-硝基氧基丙醇（3-NOP）。本研究的目的是解释3-NOP缓解作用的变异性，并使用荟萃分析方法研究饮食组成和3-NOP剂量之间的相互作用。来自13篇文章（14个实验）的数据符合纳入荟萃分析的选择标准，48个治疗平均值用于分析。平均差异计算为3-NOP处理平均值减去对照处理平均值，然后表示为对照平均值的百分比。开发了三种类型的模型：（1）一种包括3-NOP剂量、总体平均值和个体协变量;（2）中性洗涤剂纤维（NDF）、3-NOP剂量和总体平均值的组合;以及（3）从最多5个协变量的所有组合中选择一个模型，使用留一交叉验证方法进行比较。在平均3-NOP剂量为70.5 mg/kg干物质（DM）时，仅包括3-NOP剂量的模型导致CH 4产量（g/d）、产量（g/kg干物质摄入量）和强度（g/kg能量校正牛奶）分别显著降低32.7%、30.9%和32.6%。饮食中NDF含量越高，对于给定的3-NOP剂量，还原效率越低。当NDF含量从其平均值（329 g NDF/kg DM）增加10 g/kg DM时，3-NOP对CH 4产生的影响减弱0.633%，3-NOP对CH 4产量的影响减弱0.647%，3-NOP对CH 4强度的影响减弱0.723%。基于留一法交叉验证的分析显示，NDF和粗脂肪含量的增加降低了3-NOP的功效，而3-NOP剂量的增加增加了功效。日粮NDF含量从其平均值降低1%（10 g/kg）DM可使3-NOP降低CH 4产生的功效增加0.915%。在给定剂量和NDF水平下，膳食粗脂肪含量从其平均值降低1%（10 g/kg DM），3-NOP对CH 4产生的功效提高3.080%。对于CH 4产量，除了3-NOP剂量外，所选模型还包括膳食NDF含量和膳食粗脂肪含量，以及与NDF和粗脂肪方向相反的膳食淀粉含量。3-NOP剂量对CH 4强度的影响与其对CH 4产生的影响相似，而日粮NDF含量的影响略低。从那时起，用从试验中公布的新数据扩展先前公布的模型，提高了模型性能，因此证明了如果有更广泛的数据可用，定期更新荟萃分析的价值。
Ruminants, particularly dairy and beef cattle, contribute to climate change through mostly enteric methane emissions. Several mitigating options have been proposed, including the feed additive 3-nitrooxypropanol (3-NOP). The objectives of this study were to explain the variability in the mitigating effect of 3-NOP and to investigate the interaction between diet composition and 3-NOP dose, using meta-analytical approaches. Data from 13 articles (14 experiments) met the selection criteria for inclusion in the meta-analysis, and 48 treatment means were used for the analysis. Mean differences were calculated as 3-NOP treatment mean minus control treatment mean and then expressed as a percentage of the control mean. Three types of models were developed: (1) one including 3-NOP dose, overall mean, and individual covariate; (2) a combination of neutral detergent fiber (NDF), 3-NOP dose, and overall mean; and (3) one selected model from all combinations of up to 5 covariates, which were compared using a leave-one-out cross validation method. Models including only 3-NOP dose resulted in a significant reduction of 32.7%, 30.9%, and 32.6% for CH4 production (g/d), yield (g/kg dry matter intake), and intensity (g/kg energy-corrected milk), respectively, at an average 3-NOP dose of 70.5 mg/kg dry matter (DM). The greater the NDF content in the diet, the lower the reduction efficiency for a given 3-NOP dose. For 10 g/kg DM increase in NDF content from its mean (329 g of NDF/kg of DM) the 3-NOP effect on CH4 production was impaired by 0.633%, the 3-NOP effect on CH4 yield by 0.647%, and the 3-NOP effect on CH4 intensity by 0.723%. The analysis based on leave-one-out cross validation showed an increase in NDF and crude fat content reduces efficacy of 3-NOP and an increase in 3-NOP dose increases efficacy. A 1% (10 g/kg) DM decrease in dietary NDF content from its mean may increase the efficacy of 3-NOP in reducing CH4 production by 0.915%. A 1% (10 g/kg DM) decrease in dietary crude fat content from its mean enhances the efficacy of 3-NOP on CH4 production by 3.080% at a given dose and NDF level. For CH4 yield, next to 3-NOP dose, dietary NDF content and dietary crude fat content were included in the selected model, but also dietary starch content with an opposite direction to NDF and crude fat. The effect of 3-NOP dose on CH4 intensity was similar to its effect on CH4 production, whereas the effect of dietary NDF content was slightly lower. Expanding the previously published models with the newly available data published from trials since then improved model performance, hence demonstrating the value of regularly updating meta-analyses if a wider range of data becomes available.
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DOI：
10.2903/j.efsa.2021.6905
发表时间：
2021-11
期刊：
EFSA journal. European Food Safety Authority
影响因子：
--
作者：
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP);Bampidis V;Azimonti G;Bastos ML;Christensen H;Dusemund B;Fašmon Durjava M;Kouba M;López-Alonso M;López Puente S;Marcon F;Mayo B;Pechová A;Petkova M;Ramos F;Sanz Y;Villa RE;Woutersen R;Aquilina G;Bories G;Brantom PG;Gropp J;Svensson K;Tosti L;Anguita M;Galobart J;Manini P;Tarrès-Call J;Pizzo F
通讯作者：
Pizzo F
影响因子：
3.5
作者：
van Gastelen, Sanne;Dijkstra, Jan;Bannink, Andre
通讯作者：
Bannink, Andre
影响因子：
2
作者：
van Lingen, Henk J.;Fadel, James G.;Dijkstra, Jan
通讯作者：
Dijkstra, Jan
影响因子：
3.3
作者：
Romero-Perez, A.;Okine, E. K.;Beauchemin, K. A.
通讯作者：
Beauchemin, K. A.
DOI：
10.1073/pnas.2111294119
发表时间：
2022-05-17
影响因子：
11.1
作者：
通讯作者：
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