Retinal adaptation abnormalities in primary open-angle glaucoma.
Retinal adaptation abnormalities in primary open-angle glaucoma.
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原发性开角型青光眼的视网膜适应异常。
DOI：
10.1167/iovs.14-15725
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发表时间：
2015
影响因子：
4.4
通讯作者：
Zaidi,Qasim
中科院分区：
文献类型：
--
作者：
Dul,Mitchell;Ennis,Robert;Radner,Shira;Lee,Barry;Zaidi,Qasim
目的：动态的颜色和亮度适应对视觉功能至关重要。青光眼对视网膜神经节细胞（RGCs）的影响可能会损害这些功能。我们以前使用缓慢的动态变化的光在中等强度下测量的速度和幅度的RGC减法适应。我们使用相同的程序来测试与年龄相似的对照组相比，RGC异常是否会导致青光眼患者适应较慢和较弱。我们通过沿着分离出小视网膜神经节细胞、细小视网膜神经节细胞和大视网膜神经节细胞的三个主要颜色轴测试沿着，评估了特定类别视网膜神经节细胞的适应缺陷。我们对10例原发性开角型青光眼患者和他们年龄相仿的对照者的每只眼睛，在中心注视点和8个上级、下部、鼻侧和颞侧注视点，测量了适应沿着三个主轴的1/32 Hz颜色调制的速度和幅度。在所有15个比较中（5个位置× 3个颜色轴），青光眼患者的平均适应比对照组慢且弱。适应发展缓慢，在中央目标比在8偏心控制，但不是为患者。即使在视网膜位置，受影响眼和对照眼的适应速度和幅度也不同，临床视野没有显示视野损失。对于所有三类RGC，青光眼患者的神经适应性较弱。由于适应异常甚至在没有表现出视野损失的视网膜位置也表现出来，这种新的评估形式可能提供对青光眼的功能性洞察和早期诊断工具。
Purpose.: Dynamic color and brightness adaptation are crucial for visual functioning. The effects of glaucoma on retinal ganglion cells (RGCs) could compromise these functions. We have previously used slow dynamic changes of light at moderate intensities to measure the speed and magnitude of subtractive adaptation in RGCs. We used the same procedure to test if RGC abnormalities cause slower and weaker adaptation for patients with glaucoma when compared to age-similar controls. We assessed adaptation deficits in specific classes of RGCs by testing along the three cardinal color axes that isolate konio, parvo, and magno RGCs.Methods.: For one eye each of 10 primary open-angle glaucoma patients and their age-similar controls, we measured the speed and magnitude of adapting to 1/32 Hz color modulations along the three cardinal axes, at central fixation and 8 superior, inferior, nasal, and temporal to fixation.Results.: In all 15 comparisons (5 locations× 3 color axes), average adaptation was slower and weaker for glaucoma patients than for controls. Adaptation developed slower at central targets than at 8 eccentricities for controls, but not for patients. Adaptation speed and magnitude differed between affected and control eyes even at retinal locations showing no visual field loss with clinical perimetry.Conclusions.: Neural adaptation is weaker in glaucoma patients for all three classes of RGCs. Since adaptation abnormalities are manifested even at retinal locations not exhibiting a visual field loss, this novel form of assessment may offer a functional insight into glaucoma and an early diagnosis tool.
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影响因子：
4.4
作者：
H. Quigley;Rosario Sanchez;G. Dunkelberger;N. L'Hernault;T. Baginski
通讯作者：
H. Quigley;Rosario Sanchez;G. Dunkelberger;N. L'Hernault;T. Baginski
影响因子：
1.8
作者：
Q. Zaidi;Daniel Halevy
通讯作者：
Q. Zaidi;Daniel Halevy
DOI：
10.1364/josaa.31.00a220
发表时间：
2014-04-01
影响因子：
1.9
作者：
Bachy, Romain;Zaidi, Qasim
通讯作者：
Zaidi, Qasim
影响因子：
17.8
作者：
Hood DC;Raza AS;de Moraes CG;Liebmann JM;Ritch R
通讯作者：
Ritch R
影响因子：
2.5
作者：
Sun, H;Smithson, HE;Lee, BB
通讯作者：
Lee, BB