Connectivity of neuronal populations within and between areas of primate somatosensory cortex.
Connectivity of neuronal populations within and between areas of primate somatosensory cortex.
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DOI：
10.1007/s00429-018-1671-8
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发表时间：
2018-07
影响因子：
3.1
通讯作者：
Négyessy L
中科院分区：
文献类型：
--
作者：
Pálfi E;Zalányi L;Ashaber M;Palmer C;Kántor O;Roe AW;Friedman RM;Négyessy L
大脑皮层的功能通过区域内和区域间水平分布的神经元群体的相互作用而出现。然而，这些相互作用的连接基础还没有得到很好的理解。本研究采用束追踪和光学内在信号成像（OIS）探讨了分层组织的体感皮层区3b和1内的列大小的皮层域的电路。解剖学结果表明，前馈连接表现出较高的地形特异性，而内在和反馈连接有一个更广泛的分布。内在的和区域间的连接都是在地形上面向整个手指表示。与区域3b相比，连接的低聚类和小的皮层放大因子支持区域1的电路支架稀疏的功能表示，其整合了来自大区域的反馈到区域3b的外围信息。区域之间的快速信息交换是由粗轴突形成的地形组织，相互通路。此外，投射神经元和轴突分支斑块组的最高密度与OIS报告的功能群体反应的大小和位置相对应。这些发现在中观水平上建立了支持大脑皮层功能组织的连接基序。
Functions of the cerebral cortex emerge via interactions of horizontally distributed neuronal populations within and across areas. However, the connectional underpinning of these interactions is not well understood. The present study explores the circuitry of column-size cortical domains within the hierarchically organized somatosensory cortical areas 3b and 1 using tract tracing and optical intrinsic signal imaging (OIS). The anatomical findings reveal that feedforward connections exhibit high topographic specificity, while intrinsic and feedback connections have a more widespread distribution. Both intrinsic and inter-areal connections are topographically oriented across the finger representations. Compared to area 3b, the low clustering of connections and small cortical magnification factor supports that the circuitry of area 1 scaffolds a sparse functional representation that integrates peripheral information from a large area that is fed back to area 3b. Fast information exchange between areas is ensured by thick axons forming a topographically organized, reciprocal pathway. Moreover, the highest density of projecting neurons and groups of axon arborization patches corresponds well with the size and locations of the functional population response reported by OIS. The findings establish connectional motifs at the mesoscopic level that underpin the functional organization of the cerebral cortex.
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影响因子：
5.7
作者：
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通讯作者：
García-Cabezas MÁ
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