Feedforward and feedback projections of caudal belt and parabelt areas of auditory cortex: refining the hierarchical model.
Feedforward and feedback projections of caudal belt and parabelt areas of auditory cortex: refining the hierarchical model.
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DOI：
10.3389/fnins.2014.00072
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发表时间：
2014
影响因子：
4.3
通讯作者：
Schroeder CE
中科院分区：
文献类型：
--
作者：
Hackett TA;de la Mothe LA;Camalier CR;Falchier A;Lakatos P;Kajikawa Y;Schroeder CE
我们的灵长类听觉皮层工作模型识别出三个主要区域（核心、带、旁带），再细分为13个区域。区域之间的连接在地形上有序，与沿两个主要解剖轴（核心-带-副带和尾-吻侧）的信息流一致。值得注意的是，大多数支持该模型的连接都是使用逆行追踪技术发现的。我们对层流电路知之甚少，因为轴突末端的顺行追踪很少被使用。本研究的目的是根据对所有区域的分析，检查听觉皮层三个区域的层状投影。选取区域为：中外侧带（ML）；尾状带；和尾侧抛物线（CPB）。注射顺行示踪剂产生的数据与我们模型的主要特征一致，也有新的发现迫使修改。支持该模型的结果是：(1)ML和CM在CPB中终止的前馈投影；(2) ML和CPB的前馈投影终止于带和副带的吻侧区域；(3)反馈投影反映了从带和抛物带向核心区的输入。与模型不一致的是，ML和CPB的前馈输入收敛到吻侧内侧带。这是出乎意料的，因为CPB处于处理层次的较高阶段，主要是对所有其他带区域的反馈预测。最后，扩展模型，CM、ML和CPB的前馈投射在颞上沟的颞顶枕区（TPO）重叠，表明听觉对该区域的感觉加工有显著影响。综合结果完善了我们的工作模型，并强调需要完成对听觉皮层所有区域的层流输入的研究。他们的文件是必要的，以发展知情的假设，神经生理的影响输入到每一层和区域。
Our working model of the primate auditory cortex recognizes three major regions (core, belt, parabelt), subdivided into thirteen areas. The connections between areas are topographically ordered in a manner consistent with information flow along two major anatomical axes: core-belt-parabelt and caudal-rostral. Remarkably, most of the connections supporting this model were revealed using retrograde tracing techniques. Little is known about laminar circuitry, as anterograde tracing of axon terminations has rarely been used. The purpose of the present study was to examine the laminar projections of three areas of auditory cortex, pursuant to analysis of all areas. The selected areas were: middle lateral belt (ML); caudomedial belt (CM); and caudal parabelt (CPB). Injections of anterograde tracers yielded data consistent with major features of our model, and also new findings that compel modifications. Results supporting the model were: (1) feedforward projection from ML and CM terminated in CPB; (2) feedforward projections from ML and CPB terminated in rostral areas of the belt and parabelt; and (3) feedback projections typified inputs to the core region from belt and parabelt. At odds with the model was the convergence of feedforward inputs into rostral medial belt from ML and CPB. This was unexpected since CPB is at a higher stage of the processing hierarchy, with mainly feedback projections to all other belt areas. Lastly, extending the model, feedforward projections from CM, ML, and CPB overlapped in the temporal parietal occipital area (TPO) in the superior temporal sulcus, indicating significant auditory influence on sensory processing in this region. The combined results refine our working model and highlight the need to complete studies of the laminar inputs to all areas of auditory cortex. Their documentation is essential for developing informed hypotheses about the neurophysiological influences of inputs to each layer and area.
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影响因子：
2.5
作者：
BARNES, CL;PANDYA, DN
通讯作者：
PANDYA, DN
影响因子：
2.5
作者：
CIPOLLONI, PB;PANDYA, DN
通讯作者：
PANDYA, DN
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.
DOI：
10.1007/bf00325634
发表时间：
1971-01-01
期刊：
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE
影响因子：
--
作者：
GENESERJENSEN, FA;BLACKSTAD, TW
通讯作者：
BLACKSTAD, TW
影响因子：
2.5
作者：
CUSICK, CG;SELTZER, B;GRIGGS, E
通讯作者：
GRIGGS, E