Scars in depression: is a conceptual shift necessary to solve the puzzle?

Scars in depression: is a conceptual shift necessary to solve the puzzle?
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抑郁症的伤痕:解决这个难题是否需要观念转变?

DOI:
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发表时间:
2009
影响因子:
6.9
通讯作者:
F. Peeters
F. Peeters
中科院分区:
医学1区
文献类型:
--
作者:
M. Wichers;N. Geschwind;J. V. Os;F. Peeters

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虽然临床研究结果表明,在抑郁症的后果可能会随之而来的“疤痕”的过程中,研究“疤痕”(包括生物,心理和认知变化)的问题仍然在很大程度上没有定论。本文提出了一种新的方法来“疤痕”的概念,即(i)基于抑郁症的维度视图,(ii)使用考虑到人与环境之间动态相互作用的方法,(iii)区分抑郁症后的疤痕和实际引起抑郁症的因素如压力后的疤痕,以及(iv)介绍了一个动态的观点的概念'疤痕',因为它假设疤痕可以蜡和减弱。这种方法可能会刺激发现新的条目的谜题潜在的个体发育的脆弱性和弹性。此外,它可能提供有助于开发抑郁症新疗法的见解。
Although clinical findings suggest that in the aftermath of depression a process of ‘scarring’ may ensue, research examining the issue of ‘scars’ (including biological, psychological and cognitive changes) has remained largely inconclusive. This paper proposes a new approach to the concept of ‘scars’ that is (i) based on a dimensional view of depression, (ii) uses methods that take into account the dynamic interplay between the person and his context, (iii) differentiates between scars following depression and scars following the factor that actually caused the depression such as stress and (iv) introduces a dynamic view of the concept of ‘scars’ in that it hypothesizes that scars can wax and wane. This approach may stimulate the discovery of new entries in the puzzle underlying the ontogenesis of vulnerability and resilience. Furthermore, it may provide insights that help to develop new therapies for depression.
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