The importance of basal-temporal white matter to pre- and post-surgical naming ability in temporal lobe epilepsy.
The importance of basal-temporal white matter to pre- and post-surgical naming ability in temporal lobe epilepsy.
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DOI：
10.1016/j.nicl.2022.102963
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
McDonald CR
中科院分区：
文献类型：
--
作者：
Kaestner E;Stasenko A;Ben-Haim S;Shih J;Paul BM;McDonald CR
梭形相关白质的健康状况影响颞叶癫痫患者的命名能力。更健康的右脑梭形相关白质可能是手术后的保护性物质。听觉和视觉命名结果中神经生物学差异的一些证据。新的研究强调了以梭形回为中心的基底-颞叶皮质对颞叶癫痫(TLE)手术前命名能力和术后命名结果的重要性。在这项研究中，我们调查了白质网络的完整性是否会影响命名能力和手术后命名下降的风险。在一项前瞻性纵向研究中，从两个癫痫中心招募了耐药的TLE患者。手术前数据包括50名健康对照组、47名左侧TLE(L-TLE)和41名右侧TLE(R-TLE)患者。所有参与者都完成了术前T1加权和弥散加权磁共振成像(DMRI)，以及听觉和视觉命名的神经心理学测试。19例L-TLE和18例R-TLE患者接受了前颞叶切除术，并完成了术后神经心理测试。计算术前位于梭形新皮质正下方的白质(即浅层白质；SWM)和与基底-颞叶皮质相连的深层白质束[下纵束(ILF)和额枕下束(IFOF)]的分数各向异性(FA)。临床变量、海马体体积和每个白质束或区域的FA以命名分数或命名分数的变化作为主要结果进行线性回归分析。手术前，双侧ILF、双侧IFOF和左侧梭形SWM的FA较高与较好的视觉和听觉命名评分相关(经FDR校正后，所有PS均为0.05)。在L-TLE患者中，较高的术前FA也与术后较少的命名下降有关，但结果在不同的椎管中有所不同。当只包括具有典型语言优势的患者时，只有右侧梭形SWM的完整性与较少的视觉命名下降相关(p=0.0018)。尽管广泛的白质网络可能有助于术前命名能力，但对侧(右侧)梭形SWM的储备能力可能对缓解L-TLE患者ATL后视觉命名能力下降具有重要意义。这表明，对连接基底区和更广泛语言网络的结构网络的研究对理解TLE手术前和术后的命名都有意义。
The health of fusiform-associated white matter affects naming ability in temporal lobe epilepsy. Healthier right hemisphere fusiform-associated white matter may be protective post-surgically. Some evidence for neurobiological distinction in auditory and visual naming outcomes. Emerging research highlights the importance of basal-temporal cortex, centered on the fusiform gyrus, to both pre-surgical naming ability and post-surgical naming outcomes in temporal lobe epilepsy (TLE). In this study, we investigate whether integrity of the white matter network that interconnects this basal region to the distributed language network affects naming ability and risk for post-surgical naming decline. Patients with drug-resistant TLE were recruited from two epilepsy centers in a prospective longitudinal study. The pre-surgical dataset included 50 healthy controls, 47 left TLE (L-TLE), and 41 right TLE (R-TLE) patients. All participants completed pre-surgical T1- and diffusion-weighted MRI (dMRI), as well as neuropsychological tests of auditory and visual naming. Nineteen L-TLE and 18 R-TLE patients underwent anterior temporal lobectomy (ATL) and also completed post-surgical neuropsychological testing. Pre-surgical fractional anisotropy (FA) of the white matter directly beneath the fusiform neocortex (i.e., superficial white matter; SWM) and of deep white matter tracts with connections to the basal-temporal cortex [inferior longitudinal fasciculus (ILF) and inferior frontal occipital fasciculus (IFOF)] was calculated. Clinical variables, hippocampal volume, and FA of each white matter tract or region were examined in linear regressions with naming scores, or change in naming scores, as the primary outcomes. Pre-surgically, higher FA in the bilateral ILF, bilateral IFOF, and left fusiform SWM was associated with better visual and auditory naming scores (all ps < 0.05 with FDR correction). In L-TLE, higher pre-surgical FA was also associated with less naming decline post-surgically, but results varied across tracts. When including only patients with typical language dominance, only integrity of the right fusiform SWM was associated with less visual naming decline (p = .0018). Although a broad network of white matter network matter may contribute to naming ability pre-surgically, the reserve capacity of the contralateral (right) fusiform SWM may be important for mitigating visual naming decline following ATL in L-TLE. This shows that the study of the structural network interconnecting the basal-temporal region to the wider language network has implications for understanding both pre- and post-surgical naming in TLE.
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影响因子：
4.1
作者：
Abdallah, Chifaou;Brissart, Helene;Maillard, Louis
通讯作者：
Maillard, Louis
影响因子：
5.1
作者：
Giovagnoli, A. R.;Parente, A.;Villani, F.
通讯作者：
Villani, F.
影响因子：
2.6
作者：
Giovagnoli, AR;Erbetta, A;Avanzini, G
通讯作者：
Avanzini, G
影响因子：
11.2
作者：
Berl, Madison M.;Zimmaro, Lauren A.;Khan, Omar I.;Dustin, Irene;Ritzl, Eva;Duke, Elizabeth S.;Sepeta, Leigh N.;Sato, Susumu;Theodore, William H.;Gaillard, William D.
通讯作者：
Gaillard, William D.
DOI：
10.1016/j.yebeh.2010.08.004
发表时间：
2011-02
期刊：
Epilepsy & behavior : E&B
影响因子：
--
作者：
Binder JR
通讯作者：
Binder JR