Functional MRI is a valid noninvasive alternative to Wada testing.

Functional MRI is a valid noninvasive alternative to Wada testing.
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DOI:
10.1016/j.yebeh.2010.08.004
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发表时间:
2011-02
期刊:
Epilepsy & behavior : E&B
影响因子:
--
通讯作者:
Binder JR
Binder JR
中科院分区:
其他
文献类型:
--
作者:
Binder JR

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部分切除前颞叶(ATL)是治疗难治性颞叶癫痫的一种非常有效的手术治疗方法,但大约一半接受左ATL切除术的患者术后语言或言语记忆功能下降。最近的两项研究表明,术前功能磁共振成像可以预测术后命名和言语记忆的变化,在这样的患者。最重要的是,相对于单独使用的其他非侵入性措施,fMRI显著提高了预测的准确性。在这些研究中,增加颈动脉内异戊巴比妥(Wada)试验的语言和记忆侧化数据并没有提高预测准确性。因此,功能磁共振成像为患者和从业者提供了一个安全,非侵入性的,并充分验证的工具,使更好地了解决策的基础上进行择期手术的认知风险的定量评估。
Partial removal of the anterior temporal lobe (ATL) is a highly effective surgical treatment for intractable temporal lobe epilepsy, yet roughly half of patients who undergo left ATL resection show decline in language or verbal memory function postoperatively. Two recent studies demonstrate that preoperative fMRI can predict postoperative naming and verbal memory changes in such patients. Most importantly, fMRI significantly improves the accuracy of prediction relative to other noninvasive measures used alone. Addition of language and memory lateralization data from the intracarotid amobarbital (Wada) test did not improve prediction accuracy in these studies. Thus, fMRI provides patients and practitioners with a safe, non-invasive, and well-validated tool for making better-informed decisions regarding elective surgery based on a quantitative assessment of cognitive risk.
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