Omega-3 Fatty Acids and Cancer
Omega-3 Fatty Acids and Cancer
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Omega-3 脂肪酸与癌症
DOI：
10.1177/1420326x03036999
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发表时间：
2003
影响因子：
3.6
通讯作者：
A. Simopoulos
中科院分区：
文献类型：
--
作者：
A. Simopoulos
流行病学研究和动物实验表明，omega-3脂肪酸对一些常见的癌症，特别是乳腺癌，结肠癌和前列腺癌具有保护作用。涉及许多机制，包括通过抑制ω-6脂肪酸产生类二十烷酸来抑制肿瘤转化、抑制细胞生长、增强细胞凋亡和抗血管生成;抑制环氧化酶-2（考克斯-2）、白细胞介素-1（IL-1）和IL-6基因表达。最近对乳腺癌患者的干预研究表明，ω-3脂肪酸，特别是二十二碳六烯酸（DHA），可增加对化学预防剂的反应。在结直肠癌患者中，二十碳五烯酸（EPA）和DHA降低细胞增殖，并有利地调节结肠细胞增殖和凋亡之间的平衡。一般来说，均衡的omega-6：omega-3比例对正常生长和发育至关重要，并在预防和治疗许多临床疾病（包括癌症）方面发挥重要作用。对于癌症患者的预防和治疗，饮食中的omega-6和omega-3脂肪酸平衡至关重要。
Epidemiological studies and animal experiments indicate that omega-3 fatty acids exert protective effects against some common cancers, especially cancers of the breast, colon and prostate. Many mechanisms are involved, including suppression of neoplastic transformation, cell growth inhibition, and enhanced apoptosis and antiangiogenicity, through the inhibition of eicosanoid production from omega-6 fatty acids; suppression of cycloöxygenase-2 (COX-2), and interleukin-1 (IL-1) and IL-6 gene expression. Recent intervention studies in breast cancer patients indicate that omega-3 fatty acids, and docosahexaenoic acid (DHA) in particular, increase the response to chemopreventive agents. In patients with colorectal cancer, eicosapentaenoic acid (EPA) and DHA decrease cell proliferation, and modulate favourably the balance between colonic cell proliferation and apoptosis. In general, a balanced omega-6: omega-3 ratio is essential for normal growth and development, and plays an important role in the prevention and treatment of many clinical conditions, including cancer. For both prevention and treatment of cancerpatients, it is essential that the diet is balanced in omega-6 and omega-3 fatty acids.
影响因子：
29.4
作者：
BARTRAM, HP;GOSTNER, A;KASPER, H
通讯作者：
KASPER, H
脂肪和必需脂肪酸在乳腺癌发生中的作用。
DOI：
10.1093/ajcn/45.1.218
发表时间：
1987
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Ip,C
通讯作者：
Ip,C