Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting.
Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting.
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DOI：
10.3390/molecules21121719
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发表时间：
2016-12-15
期刊：
影响因子：
--
通讯作者：
DeLouise LA
中科院分区：
文献类型：
--
作者：
Palmer BC;DeLouise LA
经皮给药系统已经存在了几十年，目前的技术（例如，贴剂、软膏剂和乳膏剂）增强低分子量、亲脂性药物的皮肤渗透，所述药物在低剂量下有效。目前透皮给药研究的目的是发现增强用于疾病治疗和疫苗接种的较大亲水性药物和大分子的皮肤渗透的方法。由脂质、金属或聚合物制成的纳米载体已成功地用于增加药物或疫苗的渗透、控制药物释放以及将药物靶向到体内皮肤的特定区域。虽然需要更多的研究来确定纳米载体的安全性，但这项技术有可能将经皮给药途径的使用扩展到广泛的治疗方法。在这里，我们回顾了纳米粒子皮肤给药系统的现状，特别强调针对皮肤疾病。
Transdermal drug delivery systems have been around for decades, and current technologies (e.g., patches, ointments, and creams) enhance the skin permeation of low molecular weight, lipophilic drugs that are efficacious at low doses. The objective of current transdermal drug delivery research is to discover ways to enhance skin penetration of larger, hydrophilic drugs and macromolecules for disease treatment and vaccination. Nanocarriers made of lipids, metals, or polymers have been successfully used to increase penetration of drugs or vaccines, control drug release, and target drugs to specific areas of skin in vivo. While more research is needed to identify the safety of nanocarriers, this technology has the potential to expand the use of transdermal routes of administration to a wide array of therapeutics. Here, we review the current state of nanoparticle skin delivery systems with special emphasis on targeting skin diseases.
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影响因子：
14.2
作者：
De Benedetto, Anna;Rafaels, Nicholas M;McGirt, Laura Y;Ivanov, Andrei I;Georas, Steve N;Cheadle, Chris;Berger, Alan E;Zhang, Kunzhong;Vidyasagar, Sadasivan;Yoshida, Takeshi;Boguniewicz, Mark;Hata, Tissa;Schneider, Lynda C;Hanifin, Jon M;Gallo, Richard L;Novak, Natalija;Weidinger, Stephan;Beaty, Terri H;Leung, Donald Y M;Barnes, Kathleen C;Beck, Lisa A
通讯作者：
Beck, Lisa A
影响因子：
41.2
作者：
Deng Y;Ediriwickrema A;Yang F;Lewis J;Girardi M;Saltzman WM
通讯作者：
Saltzman WM
影响因子：
5.5
作者：
Contado C
通讯作者：
Contado C
影响因子：
5.8
作者：
Bessar, Hagar;Venditti, Iole;Fratoddi, Ilaria
通讯作者：
Fratoddi, Ilaria
DOI：
10.1016/j.ejpb.2008.08.007
发表时间：
2009-06-01
影响因子：
4.9
作者：
Brandner, Johanna M.
通讯作者：
Brandner, Johanna M.