Multimodal Neuroimaging in Schizophrenia: Description and Dissemination.

Multimodal Neuroimaging in Schizophrenia: Description and Dissemination.
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DOI:
10.1007/s12021-017-9338-9
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发表时间:
2017-10
期刊:
影响因子:
3
通讯作者:
Calhoun VD
Calhoun VD
中科院分区:
医学4区
文献类型:
--
作者:
Aine CJ;Bockholt HJ;Bustillo JR;Cañive JM;Caprihan A;Gasparovic C;Hanlon FM;Houck JM;Jung RE;Lauriello J;Liu J;Mayer AR;Perrone-Bizzozero NI;Posse S;Stephen JM;Turner JA;Clark VP;Calhoun VD

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在本文中,我们描述了精神分裂症中多模式神经成像数据的开放式收集,以释放到社区的数据。认知构建体。在〜200个志愿者的子集上获得了三个假设驱动范式的磁态范围还从大多数参与者那里收集了数据,并通过唾液样品收集了遗传物质,并已为全基因组键入多态性数据以及全基因组甲基化数据也来自单个研究以及我们的数据驱动的多模式分析(例如,对网络结构和网络动力学以及多型fmri数据分析的多模式检查)。所有数据将通过Mind Research网络的协作信息和神经影像套件(Coins)发布。 本文的在线版本(doi:10.1007/s12021-017-9338-9)包含补充材料,可供授权用户使用。
In this paper we describe an open-access collection of multimodal neuroimaging data in schizophrenia for release to the community. Data were acquired from approximately 100 patients with schizophrenia and 100 age-matched controls during rest as well as several task activation paradigms targeting a hierarchy of cognitive constructs. Neuroimaging data include structural MRI, functional MRI, diffusion MRI, MR spectroscopic imaging, and magnetoencephalography. For three of the hypothesis-driven projects, task activation paradigms were acquired on subsets of ~200 volunteers which examined a range of sensory and cognitive processes (e.g., auditory sensory gating, auditory/visual multisensory integration, visual transverse patterning). Neuropsychological data were also acquired and genetic material via saliva samples were collected from most of the participants and have been typed for both genome-wide polymorphism data as well as genome-wide methylation data. Some results are also presented from the individual studies as well as from our data-driven multimodal analyses (e.g., multimodal examinations of network structure and network dynamics and multitask fMRI data analysis across projects). All data will be released through the Mind Research Network’s collaborative informatics and neuroimaging suite (COINS). The online version of this article (doi:10.1007/s12021-017-9338-9) contains supplementary material, which is available to authorized users.
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