The ecology of viruses in urban rodents with a focus on SARS-CoV-2.

The ecology of viruses in urban rodents with a focus on SARS-CoV-2.
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DOI:
10.1080/22221751.2023.2217940
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发表时间:
2023-12
影响因子:
13.2
通讯作者:
--
中科院分区:
医学2区
文献类型:
--
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野生动物自然会感染一系列病毒,其中一些可能是人畜共患病毒。在人类COVID大流行期间,啮齿动物也有可能从人类身上感染SARS-CoV-2,即所谓的反向人畜共患病。为了研究这一点,我们在2020年人类COVID-19大流行期间从城市环境中取样了大鼠(褐家鼠)和小鼠(森林Apodemus sylvaticus)。我们对肺、肠道组织和粪便进行了病毒宏基因组测序,PCR筛选了SARS-CoV-2,并进行了血清学检测,检测了抗SARS-CoV-2刺突抗体。我们描述了在这两种啮齿动物中发现的病毒的范围。我们没有发现SARS-CoV-2感染的分子证据,尽管在大鼠中我们发现了肺部抗体反应和中和能力的证据,这些证据与暴露于SARS-CoV-2和/或暴露于导致交叉反应抗体的其他病毒的大鼠一致。
Wild animals are naturally infected with a range of viruses, some of which may be zoonotic. During the human COVID pandemic there was also the possibility of rodents acquiring SARS-CoV-2 from people, so-called reverse zoonoses. To investigate this, we sampled rats (Rattus norvegicus) and mice (Apodemus sylvaticus) from urban environments in 2020 during the human COVID-19 pandemic. We metagenomically sequenced lung and gut tissue and faeces for viruses, PCR screened for SARS-CoV-2, and serologically surveyed for anti-SARS-CoV-2 Spike antibodies. We describe the range of viruses that we found in these two rodent species. We found no molecular evidence of SARS-CoV-2 infection, though in rats we found lung antibody responses and evidence of neutralization ability that are consistent with rats being exposed to SARS-CoV-2 and/or exposed to other viruses that result in cross-reactive antibodies.
对SARS-COV-2和其他冠状病毒的啮齿动物害虫的监视。
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