Assessment of Neuropsychological Function in Veterans With Blast-Related Mild Traumatic Brain Injury and Subconcussive Blast Exposure.
Assessment of Neuropsychological Function in Veterans With Blast-Related Mild Traumatic Brain Injury and Subconcussive Blast Exposure.
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DOI：
10.3389/fpsyg.2021.686330
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发表时间：
2021
影响因子：
3.8
通讯作者：
Morey RA
中科院分区：
文献类型：
--
作者：
Clausen AN;Bouchard HC;VA Mid-Atlantic MIRECC Workgroup;Welsh-Bohmer KA;Morey RA
目的：大多数战斗相关的头部损伤与爆炸暴露有关。虽然患有轻度创伤性脑损伤（mTBI）的退伍军人报告了认知投诉并表现出较差的神经心理学表现，但几乎没有证据检查亚震荡爆炸暴露的影响，这不符合暴露后急性期mTBI的临床症状标准。我们比较了战斗相关冲击波mTBI和战斗相关亚震荡冲击波暴露对退伍军人神经心理学表现的慢性影响。研究方法：9/11后退伍军人与战斗相关的亚震荡爆炸暴露（n = 33），战斗相关的爆炸mTBI（n = 26），和对照组（n = 33）没有战斗相关的爆炸暴露，完成了智力和执行功能，处理速度和工作记忆的神经心理学评估，通过NIH工具箱，临床精神病理学评估，对爆炸暴露和非爆炸相关头部损伤的回顾性说明，以及自我报告的当前药物治疗情况。采用Huber稳健回归比较各组的神经心理学表现。结果如下：与对照组相比，与战斗相关的冲击波mTBI和亚震荡冲击波暴露的退伍军人显示出显着较慢的处理速度。在调整创伤后应激障碍和抑郁症状后，那些与战斗相关的mTBI表现出比对照组更慢的处理速度。结论：战斗相关爆炸mTBI组的退伍军人表现出较慢的处理速度相对于控制，即使在控制PTSD和抑郁症。认知没有显着差异subconcussive和对照组或subconcussive和战斗相关的冲击波mTBI组。结果表明，神经认知评估可能不够敏感，以检测亚震荡冲击波暴露的长期影响，或精神症状可能更好地解释认知后遗症后，战斗相关的亚震荡冲击波暴露或战斗相关的冲击波mTBI。
Objective: The majority of combat-related head injuries are associated with blast exposure. While Veterans with mild traumatic brain injury (mTBI) report cognitive complaints and exhibit poorer neuropsychological performance, there is little evidence examining the effects of subconcussive blast exposure, which does not meet clinical symptom criteria for mTBI during the acute period following exposure. We compared chronic effects of combat-related blast mTBI and combat-related subconcussive blast exposure on neuropsychological performance in Veterans. Methods: Post-9/11 Veterans with combat-related subconcussive blast exposure (n = 33), combat-related blast mTBI (n = 26), and controls (n = 33) without combat-related blast exposure, completed neuropsychological assessments of intellectual and executive functioning, processing speed, and working memory via NIH toolbox, assessment of clinical psychopathology, a retrospective account of blast exposures and non-blast-related head injuries, and self-reported current medication. Huber Robust Regressions were employed to compare neuropsychological performance across groups. Results: Veterans with combat-related blast mTBI and subconcussive blast exposure displayed significantly slower processing speed compared with controls. After adjusting for post-traumatic stress disorder and depressive symptoms, those with combat-related mTBI exhibited slower processing speed than controls. Conclusion: Veterans in the combat-related blast mTBI group exhibited slower processing speed relative to controls even when controlling for PTSD and depression. Cognition did not significantly differ between subconcussive and control groups or subconcussive and combat-related blast mTBI groups. Results suggest neurocognitive assessment may not be sensitive enough to detect long-term effects of subconcussive blast exposure, or that psychiatric symptoms may better account for cognitive sequelae following combat-related subconcussive blast exposure or combat-related blast mTBI.
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影响因子：
--
作者：
Bryden, Daniel W.;Tilghman, Jessica I.;Hinds, Sidney R., II
通讯作者：
Hinds, Sidney R., II
影响因子：
4.7
作者：
Aupperle RL;Melrose AJ;Stein MB;Paulus MP
通讯作者：
Paulus MP
影响因子：
4.2
作者：
Dikmen, Sureyya;Machamer, Joan;Temkin, Nancy
通讯作者：
Temkin, Nancy
剥夺后的心理健康（PDMH）研究和存储库：美国阿富汗和伊拉克时代退伍军人的多站点研究。
影响因子：
3.1
作者：
Brancu M;Wagner HR;Morey RA;Beckham JC;Calhoun PS;Tupler LA;Marx CE;Taber KH;Hurley RA;Rowland J;McDonald SD;Hoerle JM;Moore SD;Kudler HS;Weiner RD;VA Mid-Atlantic MIRECC Workgroup;Fairbank JA
通讯作者：
Fairbank JA
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y