Accelerated development of arthritis in mice lacking endothelial selectins.
Accelerated development of arthritis in mice lacking endothelial selectins.
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缺乏内皮选择素的小鼠中关节炎的加速发育。
DOI：
10.1186/ar1770
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发表时间：
2005
影响因子：
4.9
通讯作者：
Bullard DC
中科院分区：
文献类型：
--
作者：
Ruth JH;Amin MA;Woods JM;He X;Samuel S;Yi N;Haas CS;Koch AE;Bullard DC
选择素与极晚期抗原-4和CD 44一起沿着参与介导白细胞滚动相互作用，导致类风湿性关节炎发病过程中的关节募集和炎症。以前，我们发现小鼠P-选择素缺乏导致小鼠胶原免疫关节炎模型中关节炎症的加速发作。在这里，我们报告说，无论是在E-选择素或在E-选择素和P-选择素（E/P-选择素突变体）的小鼠也表现出加速发展的关节炎相比，野生型小鼠在CIA模型，这表明这些粘附分子执行重叠的功能，在调节关节疾病。对关节肿胀发生前E/P-选择素突变小鼠关节组织中细胞因子和趋化因子表达的分析显示，与野生型小鼠相比，巨噬细胞炎性蛋白-1 α和IL-1β的关节水平显著更高。在关节炎的早期和慢性阶段，IL-1β在E/P-选择素突变的关节组织中保持显著增加。总之，这些数据说明了新的发现，E-选择素和P-选择素的表达可以显着影响关节组织中细胞因子和趋化因子的产生，并表明这些粘附分子在E/P-选择素突变小鼠关节炎的发展中发挥重要的调节作用。
The selectins, along with very late antigen-4 and CD44, have been implicated in mediating leukocyte rolling interactions that lead to joint recruitment and inflammation during the pathogenesis of rheumatoid arthritis. Previously, we showed that P-selectin deficiency in mice resulted in accelerated onset of joint inflammation in the murine collagen-immunized arthritis model. Here, we report that mice deficient either in E-selectin or in E-selectin and P-selectin (E/P-selectin mutant) also exhibit accelerated development of arthritis compared with wild type mice in the CIA model, suggesting that these adhesion molecules perform overlapping functions in regulating joint disease. Analyses of cytokine and chemokine expression in joint tissue from E/P-selectin mutant mice before the onset of joint swelling revealed significantly higher joint levels of macrophage inflammatory protein-1α and IL-1β compared to wild-type mice. IL-1β remained significantly increased in E/P-selectin mutant joint tissue during the early and chronic phases of arthritis. Overall, these data illustrate the novel finding that E-selectin and P-selectin expression can significantly influence cytokine and chemokine production in joint tissue, and suggest that these adhesion molecules play important regulatory roles in the development of arthritis in E/P-selectin mutant mice.
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DOI：
10.1084/jem.191.2.313
发表时间：
2000-01-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Horai R;Saijo S;Tanioka H;Nakae S;Sudo K;Okahara A;Ikuse T;Asano M;Iwakura Y
通讯作者：
Iwakura Y
影响因子：
4.4
作者：
Kagari, T;Doi, H;Shimozato, T
通讯作者：
Shimozato, T
DOI：
10.1084/jem.183.3.1119
发表时间：
1996-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
DeGrendele HC;Estess P;Picker LJ;Siegelman MH
通讯作者：
Siegelman MH
影响因子：
--
作者：
Joosten, LAB;Lubberts, E;vandenBerg, WB
通讯作者：
vandenBerg, WB
影响因子：
64.8
作者：
Austrup, F;Vestweber, D;Hamann, A
通讯作者：
Hamann, A