Associations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis.
Associations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis.
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DOI：
10.1186/s13223-021-00625-3
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发表时间：
2021-11-24
期刊：
影响因子：
--
通讯作者：
Camargo MC
中科院分区：
文献类型：
--
作者：
Alvarez CS;Avilés-Santa ML;Freedman ND;Perreira KM;Garcia-Bedoya O;Kaplan RC;Daviglus ML;Graubard BI;Talavera GA;Thyagarajan B;Camargo MC
卫生假说认为，接触微生物会降低患哮喘和其他与生殖器相关疾病的风险。幽门螺杆菌和甲型肝炎病毒（HAV）是常见的粪口感染。我们的研究目的是在西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）中检查这些药物与哮喘的血清阳性关系。共有12，471名HCHS/SOL参与者自我报告医生诊断的哮喘和抗H. pylori和抗-HAV被包括在这个横断面分析中。多变量逻辑回归模型用于估计血清阳性与哮喘的每种药物的总体相关性的比值比和95%置信区间。还按西班牙裔/拉丁裔背景对分析进行分层。吸烟状态和出生的影响修改进行了测试。还考虑了仅限于肺量测定定义的慢性阻塞性肺疾病（COPD）患者的分析。哮喘的加权总患病率为16.6%。H. pylori感染率为56.6%，HAV感染率为76.6%，且在西班牙裔/拉丁裔背景之间存在显著差异。在考虑了年龄、性别、教育和其他关键混杂因素后，我们发现H。pylori或HAV血清阳性与哮喘（有和无COPD），无论是所有个人的组合或任何六个特定的背景。吸烟和出生没有显著的相互作用。我们的研究结果并不支持H的作用。pylori或HAV，作为HCHS/SOL中大量不同西班牙裔/拉丁裔人群中哮喘卫生假说的证据。试验注册NCT 02060344
The hygiene hypothesis posits that microbial exposure reduces risk of asthma and other respiratory-related diseases. Helicobacter pylori and hepatitis A virus (HAV) are common fecal–oral infections. Our study aimed to examine associations of seropositivity to these agents with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). A total of 12,471 HCHS/SOL participants with baseline data on self-reported physician-diagnosed asthma, and antibodies anti-H. pylori and anti-HAV were included in this cross-sectional analysis. Multivariable logistic regression models were used to estimate the odds ratios and 95% confidence intervals for the overall associations of seropositivity to each agent with asthma. Analyses were also stratified by Hispanic/Latino background. Effect modification by smoking status and nativity were tested. An analysis restricted to individuals with spirometry-defined chronic obstructive pulmonary disease (COPD) was also considered. The weighted overall prevalence of asthma was 16.6%. The weighted seroprevalence of H. pylori was 56.6% and of HAV was 76.6%, and they significantly differed by Hispanic/Latino background. After accounting for age, sex, education and other key confounders, we found no associations between H. pylori or HAV seropositivity with asthma (with and without COPD), either for all individuals combined or for any of the six specific backgrounds. There were no significant interactions by smoking and nativity. Our findings did not provide support for the role of H. pylori or HAV, as evidence of the hygiene hypothesis in asthma among the large and diverse Hispanic/Latino populations of the HCHS/SOL. Trial registration NCT02060344
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影响因子：
5.9
作者：
Chen, Cheng;Xun, Pengcheng;He, Ka
通讯作者：
He, Ka
影响因子：
7.7
作者：
Fullerton, Donna;Britton, John R.;Fogarty, Andrew W.
通讯作者：
Fogarty, Andrew W.
影响因子：
0.3
作者：
Farabi, Nabila;Song, SuJin;Song, Won O.
通讯作者：
Song, Won O.
影响因子：
5.6
作者：
Sorlie, Paul D.;Aviles-Santa, Larissa M.;Wassertheil-Smoller, Sylvia;Kaplan, Robert C.;Daviglus, Martha L.;Giachello, Aida L.;Schneiderman, Neil;Raij, Leopoldo;Talavera, Gregory;Allison, Matthew;Lavange, Lisa;Chambless, Lloyd E.;Heiss, Gerardo
通讯作者：
Heiss, Gerardo
DOI：
10.3109/02770903.2014.930480
发表时间：
2014-11
期刊：
The Journal of asthma : official journal of the Association for the Care of Asthma
影响因子：
--
作者：
Mirabelli MC;Beavers SF;Flanders WD;Chatterjee AB
通讯作者：
Chatterjee AB