Blast-induced cochlear synaptopathy in chinchillas.
Blast-induced cochlear synaptopathy in chinchillas.
复制标题
DOI：
10.1038/s41598-018-28924-7
复制
发表时间：
2018-07-16
影响因子：
4.6
通讯作者：
Liberman MC
中科院分区：
文献类型：
--
作者：
Hickman TT;Smalt C;Bobrow J;Quatieri T;Liberman MC
当暴露于持续的高水平噪声时，耳蜗神经元比毛细胞（HC）更容易受到损伤：暴露导致暂时性阈值偏移（TTS）而没有永久性HC损伤可以破坏带状突触，永久性地沉默它们以前激活的耳蜗神经元。虽然这种“隐性听力损失”对安静时的阈值影响不大，但神经变性会降低噪声中的听力，可能是耳鸣的重要诱发因素。类似的感觉病理被视为冲击伤后，即使永久性阈值移位（PTS）是最小的。我们假设，作为连续噪声，爆炸引起的TTS也可以产生耳蜗突触病与最小的HC损失。为了测试这一点，我们定制了一个冲击管的设计，以产生爆炸样的脉冲，暴露麻醉龙猫爆炸的峰值压力从160-175分贝SPL，并检查由此产生的耳蜗功能障碍和组织病理学。我们发现，导致大于40 dB TTS且PTS或HC损失最小的暴露通常会导致20- 45%的突触损失。虽然突触病变的连续噪声暴露可以影响大面积的耳蜗，爆炸引起的突触病变更集中，在耳蜗中部和基底区的局部损伤灶。这些结果阐明了爆炸引起的感觉功能障碍的病理基础，并提出了爆炸损伤，隐性听力损失和耳鸣之间可能的联系。
When exposed to continuous high-level noise, cochlear neurons are more susceptible to damage than hair cells (HCs): exposures causing temporary threshold shifts (TTS) without permanent HC damage can destroy ribbon synapses, permanently silencing the cochlear neurons they formerly activated. While this “hidden hearing loss” has little effect on thresholds in quiet, the neural degeneration degrades hearing in noise and may be an important elicitor of tinnitus. Similar sensory pathologies are seen after blast injury, even if permanent threshold shift (PTS) is minimal. We hypothesized that, as for continuous-noise, blasts causing only TTS can also produce cochlear synaptopathy with minimal HC loss. To test this, we customized a shock tube design to generate explosive-like impulses, exposed anesthetized chinchillas to blasts with peak pressures from 160–175 dB SPL, and examined the resultant cochlear dysfunction and histopathology. We found exposures that cause large >40 dB TTS with minimal PTS or HC loss often cause synapse loss of 20–45%. While synaptopathic continuous-noise exposures can affect large areas of the cochlea, blast-induced synaptopathy was more focal, with localized damage foci in midcochlear and basal regions. These results clarify the pathology underlying blast-induced sensory dysfunction, and suggest possible links between blast injury, hidden hearing loss, and tinnitus.
登录
查看更多内容
DOI：
10.1523/jneurosci.3389-10.2011
发表时间：
2011-01-19
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Liberman LD;Wang H;Liberman MC
通讯作者：
Liberman MC
影响因子：
5.3
作者：
Kujawa, SG;Liberman, MC
通讯作者：
Liberman, MC
DOI：
10.1523/jneurosci.2845-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kujawa SG;Liberman MC
通讯作者：
Liberman MC
影响因子：
1.2
作者：
Cave, Kara M.;Cornish, Elizabeth M.;Chandler, David W.
通讯作者：
Chandler, David W.
影响因子：
64.8
作者：
CODY, AR;RUSSELL, IJ
通讯作者：
RUSSELL, IJ