Emergence and potential for spread of Chikungunya virus in Brazil.
Emergence and potential for spread of Chikungunya virus in Brazil.
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DOI：
10.1186/s12916-015-0348-x
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发表时间：
2015-04-30
期刊：
影响因子：
9.3
通讯作者：
Vasconcelos PF
中科院分区：
文献类型：
--
作者：
Nunes MR;Faria NR;de Vasconcelos JM;Golding N;Kraemer MU;de Oliveira LF;Azevedo Rdo S;da Silva DE;da Silva EV;da Silva SP;Carvalho VL;Coelho GE;Cruz AC;Rodrigues SG;Vianez JL Jr;Nunes BT;Cardoso JF;Tesh RB;Hay SI;Pybus OG;Vasconcelos PF
2013年12月，加勒比地区通报了由亚洲基因引起的基孔肯雅病毒(CHIKV)暴发。自那以后，疫情已经蔓延到美洲的38个地区。到2014年9月，巴西北部的Oiapoque和巴西东北部的Feira de Santana确认了第一例本土CHIKV感染。我们汇编了巴西CHIKV疑似病例的流行病学和临床数据，并对2014年4月至9月期间出现症状的患者的68份血清样本进行了基于聚合酶链式反应的诊断。选择2例输入性病例和4例本土病例进行病毒增殖、RNA分离、全基因组测序和系统发育分析。然后，我们遵循疾控中心/泛美卫生组织的指导方针，评估在巴西市政当局建立CHIKV的风险。我们在巴西发现了41例输入寨卡病毒和27例本土病例。流行病学和系统发育分析表明，亚洲CHIKV基因型在Oiapoque发生了局部传播。出乎意料的是，我们还发现ECSA基因在费拉德桑塔纳中流行。ECSA基因型的推定指示病例是一名最近从安哥拉返回并在费拉·德·桑塔纳出现症状的人。我们估计，如果CHIKV在巴西建立，该国94%的城市可能发生传播，并提供巴西每种CHIKV毒株输入风险的地图。与巴西早期CHIKV暴发相关的病原学毒株属于亚洲和ECSA基因型。需要持续的监测和病媒缓解战略，以减少美洲未来CHIKV对公共卫生的影响。本文的在线版本(doi：10.1186/s12916-0150348-x)包含补充材料，授权用户可以使用。
In December 2013, an outbreak of Chikungunya virus (CHIKV) caused by the Asian genotype was notified in the Caribbean. The outbreak has since spread to 38 regions in the Americas. By September 2014, the first autochthonous CHIKV infections were confirmed in Oiapoque, North Brazil, and in Feira de Santana, Northeast Brazil. We compiled epidemiological and clinical data on suspected CHIKV cases in Brazil and polymerase-chain-reaction-based diagnostic was conducted on 68 serum samples from patients with symptom onset between April and September 2014. Two imported and four autochthonous cases were selected for virus propagation, RNA isolation, full-length genome sequencing, and phylogenetic analysis. We then followed CDC/PAHO guidelines to estimate the risk of establishment of CHIKV in Brazilian municipalities. We detected 41 CHIKV importations and 27 autochthonous cases in Brazil. Epidemiological and phylogenetic analyses indicated local transmission of the Asian CHIKV genotype in Oiapoque. Unexpectedly, we also discovered that the ECSA genotype is circulating in Feira de Santana. The presumed index case of the ECSA genotype was an individual who had recently returned from Angola and developed symptoms in Feira de Santana. We estimate that, if CHIKV becomes established in Brazil, transmission could occur in 94% of municipalities in the country and provide maps of the risk of importation of each strain of CHIKV in Brazil. The etiological strains associated with the early-phase CHIKV outbreaks in Brazil belong to the Asian and ECSA genotypes. Continued surveillance and vector mitigation strategies are needed to reduce the future public health impact of CHIKV in the Americas. The online version of this article (doi:10.1186/s12916-015-0348-x) contains supplementary material, which is available to authorized users.
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