Allelic losses on chromosome 3p are accumulated in relation to morphological changes of lung adenocarcinoma.
Allelic losses on chromosome 3p are accumulated in relation to morphological changes of lung adenocarcinoma.
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DOI：
10.1038/sj.bjc.6602005
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发表时间：
2004-09-13
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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作者：
我们使用来自 23 个原发性肺腺癌的 56 个显微解剖样本对 3p 染色体上的 9 个区域进行了等位基因型分析，以检查具有不同分化程度的个体肺腺癌的进展过程。在八个病例中发现了不同分化等级之间相同的等位基因模式。在7例中发现了从高分化部分到低分化部分的等位基因丢失的累积，在5例中发现了从低分化部分到高分化部分的等位基因丢失的累积。在三个病例中发现了不同分化等级之间的不同等位基因模式。这些结果表明 3p 等位基因丢失在肺腺癌的形态变化中发挥重要作用。我们还研究了 3p 等位基因丢失与肺腺癌组织学亚型之间的关系。乳头状肿瘤中 3p14.2 和 3p21.3 端粒区域等位基因缺失的频率（14 例中有 9 例，64%；15 例中有 11 例，73%）高于细支气管肺泡癌型肿瘤（8 例中有 1 例，13%；P=0.031；12 例中有 4 例，33%；P = 0.057）。这些结果表明3p14.2和3p21.3端粒区域的等位基因丢失与肺腺癌的增殖模式有关。
We performed allelotyping analysis at nine regions on chromosome 3p using 56 microdissected samples from 23 primary lung adenocarcinomas to examine the process of progression within individual lung adenocarcinoma with various grades of differentiation. Identical allelic patterns among various grades of differentiation were found in eight cases. Accumulation of allelic losses from high to lower differentiated portions was found in seven cases and accumulation of allelic losses from low to higher differentiated portions was found in five cases. Various allelic patterns among various grades of differentiation were found in three cases. These results suggested that allelic losses on 3p play an important role in morphological changes of lung adenocarcinomas. We also investigated the relationship between allelic losses on 3p and histological subtypes of lung adenocarcinoma. The frequencies of allelic losses at 3p14.2 and telomeric region of 3p21.3 were higher in papillary type tumour (nine out of 14, 64% and 11 out of 15, 73%) than in bronchioloalveolar carcinoma-type tumour (one out of 8, 13%; P=0.031 and four out of 12, 33%; P = 0.057). These results indicated that allelic losses at 3p14.2 and telomeric region of 3p21.3 are related to pattern of the proliferation of lung adenocarcinoma.
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影响因子：
2.2
作者：
Yamasaki, M;Takeshima, Y;Inai, K
通讯作者：
Inai, K
DOI：
10.1093/jnci/91.8.675
发表时间：
1999-04-21
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Wingo, PA;Ries, LAG;Edwards, BK
通讯作者：
Edwards, BK
影响因子：
6
作者：
Yatabe, Y;Konishi, H;Takahashi, T
通讯作者：
Takahashi, T
影响因子：
8
作者：
Wistuba, II;Behrens, C;Gazdar, AF
通讯作者：
Gazdar, AF
影响因子：
6
作者：
Maitra, A;Wistuba, II;Minna, JD
通讯作者：
Minna, JD