Atypical modulation of distant functional connectivity by cognitive state in children with Autism Spectrum Disorders.
Atypical modulation of distant functional connectivity by cognitive state in children with Autism Spectrum Disorders.
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DOI：
10.3389/fnhum.2013.00482
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发表时间：
2013
影响因子：
2.9
通讯作者：
Vaidya CJ
中科院分区：
文献类型：
--
作者：
You X;Norr M;Murphy E;Kuschner ES;Bal E;Gaillard WD;Kenworthy L;Vaidya CJ
我们研究了自闭症谱系障碍（ASD）的青春期前儿童与年龄和智商匹配的对照组儿童之间，认知状态对功能连接的调节是否存在差异。儿童在两种状态下接受功能性磁共振成像（fMRI），静息状态和持续注意力任务。使用体素方法来表征两个层次的功能连接，即局部（在体素的14mm邻域内）和远处（在体素的14mm邻域外），并为两种类型的连接图确定了显示组x状态相互作用的区域。左额叶（背外侧[BA 11, 10]，延伸到前扣带背侧[BA 32/8]和运动前[BA 6, 8, 9]）、右顶叶（中央旁小叶[BA 6]）区域的远端功能连通性；角回[BA 39/40])和左后颞中皮层（BA 19/39）表现出一种组x状态相互作用，即相对于静息状态，正常儿童的连通性减少（即成为局灶性），而ASD儿童在任务状态下的连通性增加（即成为弥散性）。高状态相关的左额回和右角回远端连通性的增加预示着ASD儿童注意力不集中的恶化。两种图论测量（整体效率和模块化）也对组x状态差异敏感，状态相关变化的大小预测ASD儿童的注意力不集中。我们的研究结果表明，随着ASD儿童从不受约束的注意力状态过渡到持续的注意力状态，额叶和顶叶区域与大脑其他部分的功能连接变得更加普遍，这可能是一种不适应的方式，因为它与日常生活中的注意力问题有关。
We examined whether modulation of functional connectivity by cognitive state differed between pre-adolescent children with Autism Spectrum Disorders (ASD) and age and IQ-matched control children. Children underwent functional magnetic resonance imaging (fMRI) during two states, a resting state followed by a sustained attention task. A voxel-wise method was used to characterize functional connectivity at two levels, local (within a voxel's 14 mm neighborhood) and distant (outside of the voxel's 14 mm neighborhood to the rest of the brain) and regions exhibiting Group × State interaction were identified for both types of connectivity maps. Distant functional connectivity of regions in the left frontal lobe (dorsolateral [BA 11, 10]; supplementary motor area extending into dorsal anterior cingulate [BA 32/8]; and premotor [BA 6, 8, 9]), right parietal lobe (paracentral lobule [BA 6]; angular gyrus [BA 39/40]), and left posterior middle temporal cortex (BA 19/39) showed a Group × State interaction such that relative to the resting state, connectivity reduced (i.e., became focal) in control children but increased (i.e., became diffuse) in ASD children during the task state. Higher state-related increase in distant connectivity of left frontal and right angular gyrus predicted worse inattention in ASD children. Two graph theory measures (global efficiency and modularity) were also sensitive to Group × State differences, with the magnitude of state-related change predicting inattention in the ASD children. Our results indicate that as ASD children transition from an unconstrained to a sustained attentional state, functional connectivity of frontal and parietal regions with the rest of the brain becomes more widespread in a manner that may be maladaptive as it was associated with attention problems in everyday life.
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通讯作者：
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