The role of mesenchymal stem cells in cancer development.
The role of mesenchymal stem cells in cancer development.
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DOI：
10.3389/fgene.2013.00261
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发表时间：
2013-11-27
影响因子：
3.7
通讯作者：
Kitagawa Y
中科院分区：
文献类型：
--
作者：
Yagi H;Kitagawa Y
间充质干细胞（MSCs）在癌症发展中的作用仍然存在争议。MSC可能通过免疫调节促进肿瘤进展，但MSC的其他肿瘤抑制作用也已被描述。这些结果之间的差异可能源于与不同组织来源、个体供体变异性和MSC注射时间相关的问题。关键受体如Toll样受体的表达在治疗的不同时间点是可变的，这也可能决定MSC对肿瘤进展的影响。然而，从恶性细胞以及周围组织和脉管系统释放的因子仍然被视为“黑匣子”。“因此，仍然很难澄清MSC在癌症发展中的具体作用。目前尚不清楚MSC是否支持或抑制肿瘤进展，但很明显，全身施用的MSC可以被招募并向肿瘤迁移。这些发现很重要，因为它们可以作为启动研究的基础，以探索将工程MSC作为新型抗肿瘤载体，用于开发肿瘤靶向治疗。
The role of mesenchymal stem cells (MSCs) in cancer development is still controversial. MSCs may promote tumor progression through immune modulation, but other tumor suppressive effects of MSCs have also beendescribed. The discrepancy between these results may arise from issues related to different tissue sources, individual donor variability, and injection timing of MSCs. The expression of critical receptors such as Toll-like receptor is variable a teach time point of treatment, which may also determine the effects of MSCs on tumor progression. However, factors released from malignant cells, as well as surrounding tissues and the vasculature, are still regarded as a “black box. ” Thus, it is still difficult to clarify the specific role of MSCs in cancer development. Whether MSCs support or suppress tumor progression is currently unclear, but it is clear that systemically administered MSCs can be recruited and migrate toward tumors. These findings are important because they can be used as a basis for initiating studies to explore the incorporation of engineered MSCs as novel anti-tumor carriers, for the development of tumor-targeted therapies.
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影响因子：
3.7
作者：
Dasari VR;Kaur K;Velpula KK;Gujrati M;Fassett D;Klopfenstein JD;Dinh DH;Rao JS
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11.5
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作者：
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