Helicobacter pylori seropositivity and risk of lung cancer.
Helicobacter pylori seropositivity and risk of lung cancer.
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DOI：
10.1371/journal.pone.0032106
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Blaser MJ
中科院分区：
文献类型：
--
作者：
Koshiol J;Flores R;Lam TK;Taylor PR;Weinstein SJ;Virtamo J;Albanes D;Perez-Perez G;Caporaso NE;Blaser MJ
肺癌是世界范围内癌症死亡的主要原因。幽门螺杆菌（H. pylori）是远端胃癌的危险因素，一些小型研究表明，H.幽门螺杆菌可能是肺癌的一个潜在危险因素。为了验证这一假设，我们对芬兰男性吸烟者的α-生育酚、β-胡萝卜素癌症预防研究（ATBC）队列中的350例肺腺癌病例、350例鳞状细胞癌病例和700例对照进行了研究。对照组按年龄和基线血清抽取日期进行一对一匹配。用酶联免疫吸附试验检测抗H. pylori全细胞和细胞毒素相关基因（CagA）抗原，我们计算了H.幽门螺杆菌血清阳性和肺癌风险的条件Logistic回归分析。H.幽门螺杆菌血清学阳性率分别为79.7%和78.5%。在调整了包年数和每天吸烟量后，H。幽门螺杆菌血清阳性与腺癌（OR：1.1，95%CI：0.75-1.6）或鳞状细胞癌（OR：1.1，95%CI：0.77-1.7）均无相关性。CagA阴性和CagA阳性H.幽门螺杆菌血清阳性。尽管早期的小规模研究表明，H。pylori可能参与肺癌的发生，H.幽门螺杆菌血清阳性似乎与肺癌无关。
Lung cancer is the leading cause of cancer mortality worldwide. Helicobacter pylori (H. pylori) is a risk factor for distal stomach cancer, and a few small studies have suggested that H. pylori may be a potential risk factor for lung cancer. To test this hypothesis, we conducted a study of 350 lung adenocarcinoma cases, 350 squamous cell carcinoma cases, and 700 controls nested within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) cohort of male Finnish smokers. Controls were one-to-one matched by age and date of baseline serum draw. Using enzyme-linked immunosorbent assays to detect immunoglobulin G antibodies against H. pylori whole-cell and cytotoxin-associated gene (CagA) antigens, we calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) for associations between H. pylori seropositivity and lung cancer risk using conditional logistic regression. H. pylori seropositivity was detected in 79.7% of cases and 78.5% of controls. After adjusting for pack-years and cigarettes smoked per day, H. pylori seropositivity was not associated with either adenocarcinoma (OR: 1.1, 95% CI: 0.75–1.6) or squamous cell carcinoma (OR: 1.1, 95% CI: 0.77–1.7). Results were similar for CagA-negative and CagA-positive H. pylori seropositivity. Despite earlier small studies suggesting that H. pylori may contribute to lung carcinogenesis, H. pylori seropositivity does not appear to be associated with lung cancer.
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影响因子：
4.3
作者：
Ece, F;Hatabay, NF;Aksoy, F
通讯作者：
Aksoy, F
影响因子：
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Chang, Ya-Jen;Kim, Hye Young;Umetsu, Dale T.
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GREENWALD, P
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作者：
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