Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China.
Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China.
复制标题
DOI：
10.1007/s10654-009-9402-3
复制
发表时间：
2009
影响因子：
13.6
通讯作者：
Hsing, Ann W.
中科院分区：
文献类型：
--
作者：
Andreotti, Gabriella;Menashe, Idan;Chen, Jinbo;Chang, Shih-Chen;Rashid, Asif;Gao, Yu-Tang;Han, Tian-Quan;Sakoda, Lori C.;Chanock, Stephen;Rosenberg, Philip S.;Hsing, Ann W.
我们研究了中国人群中8个脂代谢基因的21个单核苷酸多态性（SNPs）与血脂水平的关系。这项研究是在中国进行的一项基于人群的研究的一部分，随机选择了799名健康居民，他们提供了空腹血液并进行了面对面采访。在一般线性模型中使用趋势检验和最小二乘均值检验检查变异体与平均脂质水平之间的关联。四个SNP与血脂水平相关：LDLR rs1003723与总胆固醇相关（p趋势= 0.002）和LDL（p趋势= 0.01），LDLR rs6413503与总胆固醇相关（p趋势= 0.05），APOB rs1367117与apoB相关（p-趋势= 0.02），ABCB 11 rs49550与总胆固醇（p-趋势= 0.01）、甘油三酯（p-趋势= 0.01）和apoA（p-趋势= 0.01）相关。我们发现，在高乳制品摄入量的人群中，LDLR rs6413503对血脂水平有统计学显著影响，在高葱蔬菜摄入量的人群中，LPL rs263对血脂水平有统计学显著影响，在高红肉摄入量的人群中，APOE rs440446对血脂水平有统计学显著影响。我们在中国人中发现了以前在高加索人中发现的SNPs和血脂水平之间的新关联。这些发现为深入了解脂质代谢基因的作用以及这些基因与疾病相关的机制提供了帮助。
We examined the associations between 21 single nucleotide polymorphisms (SNPs) of eight lipid metabolism genes and lipid levels in a Chinese population. This study was conducted as part of a population-based study in China with 799 randomly selected healthy residents who provided fasting blood and an in-person interview. Associations between variants and mean lipid levels were examined using a test of trend and least squares mean test in a general linear model. Four SNPs were associated with lipid levels: LDLR rs1003723 was associated with total cholesterol (p-trend=0.002) and LDL (p-trend=0.01), LDLR rs6413503 was associated with total cholesterol (p-trend=0.05), APOB rs1367117 was associated with apoB (p-trend=0.02), and ABCB11 rs49550 was associated with total cholesterol (p-trend=0.01), triglycerides (p-trend=0.01), and apoA (p-trend=0.01). We found statistically significant effects on lipid levels for LDLR rs6413503 among those with high dairy intake, LPL rs263 among those with high allium vegetable intake, and APOE rs440446 among those with high red meat intake. We identified new associations between SNPs and lipid levels in Chinese previously found in Caucasians. These findings provide insight into the role of lipid metabolism genes, as well as the mechanisms by which these genes may be linked with disease.
登录
查看更多内容
与人类血液低密度脂蛋白胆固醇、高密度脂蛋白胆固醇或甘油三酯相关的六个新位点。
影响因子：
30.8
作者：
Kathiresan, Sekar;Melander, Olle;Guiducci, Candace;Surti, Aarti;Burtt, Noel P.;Rieder, Mark J.;Cooper, Gregory M.;Roos, Charlotta;Voight, Benjamin F.;Havulinna, Aki S.;Wahlstrand, Bjorn;Hedner, Thomas;Corella, Dolores;Tai, E. Shyong;Ordovas, Jose M.;Berglund, Goran;Vartiainen, Erkki;Jousilahti, Pekka;Hedblad, Bo;Taskinen, Marja-Riitta;Newton-Cheh, Christopher;Salomaa, Veikko;Peltonen, Leena;Groop, Leif;Altshuler, David M.;Orho-Melander, Marju
通讯作者：
Orho-Melander, Marju
影响因子：
56.9
作者：
BROWN, MS;GOLDSTEIN, JL
通讯作者：
GOLDSTEIN, JL
影响因子：
4.4
作者：
Aalto-Setälä, K;Palomäki, H;Kontula, K
通讯作者：
Kontula, K
影响因子：
5.6
作者：
Boland, Lori L.;Folsom, Aaron R.;Boerwinkle, Eric
通讯作者：
Boerwinkle, Eric
影响因子：
4.2
作者：
Licastro, Federico;Porcellini, Elisa;Corder, Elizabeth H.
通讯作者：
Corder, Elizabeth H.