Characterization of the dopamine receptor system in adult rhesus monkeys exposed to cocaine throughout gestation.
Characterization of the dopamine receptor system in adult rhesus monkeys exposed to cocaine throughout gestation.
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DOI：
10.1007/s00213-010-1847-2
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发表时间：
2010-07
影响因子：
3.4
通讯作者：
Nader, Michael A.
中科院分区：
文献类型：
--
作者：
Hamilton, Lindsey R.;Czoty, Paul W.;Gage, H. Donald;Nader, Michael A.
怀孕期间使用可卡因与胎儿大脑中多巴胺(DA)系统的变化有关。然而，关于出生前接触可卡因对出生后多巴胺能系统的影响，人们知之甚少。这项研究的目的是检测产前暴露于可卡因的成年猴子的DA受体功能。所有研究均采用出生前曾接触可卡因的雄性和雌性恒河猴(~13岁)(n=10)和对照组(n=10)。首先，使用正电子发射断层扫描和D2样受体放射性示踪剂[18F]氟来布比利(FCP)评估DA D2样受体的可用性。接下来，通过测量喹比罗(0.03-0.3 mg/kg)诱导的打哈欠来评估D3受体的功能。最后，通过测量高效D1样受体激动剂SKF81297(0.3~3.0 mg/kg)引起的眨眼反应来检测D1样受体功能。在尾状核、壳核或杏仁核中，D2样受体的可用性在不同组或性别之间没有差异。然而，与对照组猴子相比，昆匹罗在产前接触可卡因的猴子中引起了明显更多的哈欠。观察到孕期可卡因的剂量与奎比罗的峰值效应有显著的相关性。在所有猴子中，服用SKF81297引起的眨眼次数随剂量的增加而增加，这在不同组之间没有差异。这些发现表明，产前接触可卡因可能会对成年人的DA D3受体功能产生长期影响。
Cocaine use during pregnancy is associated with alterations in the dopamine (DA) system in the fetal brain. However, little is known about the effects of prenatal cocaine exposure on the postnatal dopaminergic system. The objective of the study was to examine DA receptor function in adult monkeys that were prenatally exposed to cocaine. Male and female rhesus monkeys (~13 years old) that had been prenatally exposed to cocaine (n=10) and controls (n=10) were used in all studies. First, DA D2-like receptor availability was assessed using positron emission tomography and the D2-like receptor radiotracer [18F]fluoroclebopride (FCP). Next, D3 receptor function was assessed by measuring quinpirole-induced yawning (0.03–0.3 mg/kg). Finally, D1-like receptor function was examined by measuring eye blinking elicited by the high-efficacy D1-like receptor agonist SKF81297 (0.3–3.0 mg/kg). There were no differences between groups or sexes in D2-like receptor availability in the caudate nucleus, putamen or amygdala. However, quinpirole elicited significantly more yawns in prenatally cocaine-exposed monkeys compared with control monkeys. A significant correlation between gestational dose of cocaine and peak effects of quinpirole was observed. In all monkeys, administration of SKF81297 elicited dose-dependent increases in eye blinks that did not differ between groups. These findings suggest that prenatal cocaine exposure can have long-term effects on DA D3 receptor function in adults.
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影响因子：
7.6
作者：
Czoty, Paul W.;Riddick, Natallia V.;Nader, Michael A.
通讯作者：
Nader, Michael A.
DOI：
10.1111/j.1749-6632.1998.tb09736.x
发表时间：
1998-01-01
期刊：
COCAINE: EFFECTS ON THE DEVELOPING BRAIN
影响因子：
--
作者：
Lidow, MS
通讯作者：
Lidow, MS
DOI：
10.1124/jpet.106.113571
发表时间：
2007-05-01
影响因子：
3.5
作者：
Martelle, Jennifer L.;Claytor, Renee;Nader, Michael A.
通讯作者：
Nader, Michael A.
影响因子：
2.3
作者：
FARDE, L;HALL, H;HALLDIN, C
通讯作者：
HALLDIN, C
影响因子：
5.7
作者：
Christian BT;Vandehey NT;Fox AS;Murali D;Oakes TR;Converse AK;Nickles RJ;Shelton SE;Davidson RJ;Kalin NH
通讯作者：
Kalin NH