The distribution of D2/D3 receptor binding in the adolescent rhesus monkey using small animal PET imaging.
The distribution of D2/D3 receptor binding in the adolescent rhesus monkey using small animal PET imaging.
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DOI：
10.1016/j.neuroimage.2008.10.020
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发表时间：
2009-02-15
期刊：
影响因子：
5.7
通讯作者：
Kalin NH
中科院分区：
文献类型：
--
作者：
Christian BT;Vandehey NT;Fox AS;Murali D;Oakes TR;Converse AK;Nickles RJ;Shelton SE;Davidson RJ;Kalin NH
脑中神经受体系统的PET成像在研究正常发育、神经精神疾病和开发靶向药物方面发挥了重要作用。多巴胺能系统由于其在认知功能和情绪的发展中的作用以及其被怀疑参与神经精神疾病而特别感兴趣。非人灵长类动物模型为研究神经化学变化与行为之间的关系提供了宝贵的资源。为了便于灵长类动物模型内和之间的比较，我们报告在体内D2/D3结合在一个大型队列的青少年恒河猴。在这项工作中，在体内D2/D3多巴胺受体的可用性进行了测量在青春期发育阶段（3.2 - 5.3岁）的33只恒河猴队列。使用[F-18]fallypride和高分辨率小动物PET扫描仪测量纹状体和纹状体外D2/D3结合。测量所有受试者的分布容积比（DVR），并根据年龄和性别对队列中的D2/D3结合进行组间比较。由于从单个[F-18]fallypride批次中获得了两项连续研究，因此还研究了竞争性（未标记）配体质量的影响。在该队列中，区域D2/D3受体结合的等级顺序与先前对成年恒河猴的研究没有变化，为：壳核>尾状核>腹侧纹状体>杏仁核~黑质>内侧背侧丘脑>外侧颞叶皮质~额叶皮质。DVR的变异系数范围为14% -26%，尾状核头部的变异最大。垂体中[F-18]fallypride动力学存在显著的性别差异，但在血脑屏障内的区域未观察到这一点。此外，在这个小的年龄范围内，大脑中没有区域显示出与性别或年龄相关的DVR差异。基于在整个队列中广泛注射的fallypride质量，仅在黑质，丘脑和额叶皮质中检测到显著的竞争效应，并且在所有其他区域的受试者间差异上并不明显。这些数据代表了首次报告的大型队列在体内D2/D3多巴胺全脑结合在青少年大脑，并将作为一个有价值的比较，了解多巴胺的变化，在这个关键的发展时期，并提供了一个框架，建立一个多巴胺能生物化学图谱的恒河猴。
PET imaging of the neuroreceptor systems in the brain has earned a prominent role in studying normal development, neuropsychiatric illness and developing targeted drugs. The dopaminergic system is of particular interest due to its role in the development of cognitive function and mood as well as its suspected involvement in neuropsychiatric illness. Nonhuman primate animal models provide a valuable resource for relating neurochemical changes to behavior. To facilitate comparison within and between primate models, we report in vivo D2/D3 binding in a large cohort of adolescent rhesus monkeys. In this work, the in vivo D2/D3 dopamine receptor availability was measured in a cohort of 33 rhesus monkeys in the adolescent stage of development (3.2 – 5.3 years). Both striatal and extrastriatal D2/D3 binding were measured using [F-18]fallypride with a high resolution small animal PET scanner. The distribution volume ratio (DVR) was measured for all subjects and group comparisons of D2/D3 binding among the cohort were made based on age and sex. Because two sequential studies were acquired from a single [F-18]fallypride batch, the effect of competing (unlabeled) ligand mass was also investigated. Among this cohort, the rank order of regional D2/D3 receptor binding did not vary from previous studies with adult rhesus monkeys, with: putamen > caudate > ventral striatum > amygdala ~ substantia nigra > medial dorsal thalamus > lateral temporal cortex ~ frontal cortex. The DVR coefficient of variation ranged from 14% – 26%, with the greatest variance seen in the head of the caudate. There were significant sex differences in [F-18]fallypride kinetics in the pituitary gland, but this was not observed for regions within the blood-brain barrier. Furthermore, no regions in the brain showed significant sex or age related differences in DVR within this small age range. Based on a wide range of injected fallypride mass across the cohort, significant competition effects could only be detected in the substantia nigra, thalamus, and frontal cortex, and were not evident above intersubject variability in all other regions. These data represent the first report of large cohort in vivo D2/D3 dopamine whole brain binding in the adolescent brain and will serve as a valuable comparison for understanding dopamine changes during this critical time of development and provide a framework for creating a dopaminergic biochemical atlas for the rhesus monkey.
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影响因子：
5.3
作者：
Aalto, S;Brück, A;Rinne, JO
通讯作者：
Rinne, JO
DOI：
10.1097/00004647-200209000-00011
发表时间：
2002-09-01
影响因子：
6.3
作者：
Holden, JE;Jivan, S;Doudet, DJ
通讯作者：
Doudet, DJ
影响因子：
9.9
作者：
Gilbert, D. L.;Christian, B. T.;Sallee, F. R.
通讯作者：
Sallee, F. R.
影响因子：
2.3
作者：
FARDE, L;HALL, H;HALLDIN, C
通讯作者：
HALLDIN, C
DOI：
10.1007/s002590050211
发表时间：
1998-02-01
期刊：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
影响因子：
--
作者：
Hume, SP;Gunn, RN;Jones, T
通讯作者：
Jones, T