Isotypic antibody response to plaque anaerobes in periodontal disease.
Isotypic antibody response to plaque anaerobes in periodontal disease.
复制标题
同型抗体对牙周病中菌斑厌氧菌的反应。
DOI：
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
G. Faure
中科院分区：
文献类型：
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作者：
M. Plombas;B. Gobert;A. D. de March;Marie N Kolopp Sarda;M. Sixou;M. Béné;N. Miller;G. Faure
背景
有人认为，局部产生的免疫球蛋白（IG）A可能比IgG更具有保护作用，并且龈沟液特异性伊加水平与牙周病的发病之间可能存在关系。本研究旨在探讨这一假说对4菌斑厌氧菌在龈沟液和唾液中的牙周病患者和对照组的特异性免疫反应。
方法
收集35例牙周炎患者和24例牙周健康成人（对照组）的龈沟液和全唾液。从伴放线放线菌、牙龈卟啉单胞菌、中间普雷沃氏菌和具核梭杆菌中提取抗原，并用于建立特异性酶联免疫吸附测定（ELISA）试验，以评估收集的液体中这些微生物的伊加和IgG水平。
结果
牙周炎患者龈沟液中抗4种微生物的IgG水平均显著高于对照组（P < 10 - 6）。对照组龈沟液中4种细菌的伊加水平在统计学上显著更高（所有比较P < 10（-7））。对照组的特异性唾液伊加水平也显著高于患者（所有比较P < 0.02）。
结论
这些数据支持特定伊加针对参与牙周病发病和发展的口腔微生物的潜在保护作用。
BACKGROUND
It has been suggested that locally produced immunoglobulin (Ig)A could be more protective than IgG and that there could be a relationship between crevicular fluid-specific IgA levels and the onset of periodontal disease. This study was designed to investigate this hypothesis regarding specific immune responses towards 4 plaque anaerobes in gingival crevicular fluid and saliva from patients with periodontopathies and controls.
METHODS
Gingival crevicular fluid (GCF) and whole saliva were collected from 35 adults with periodontitis and 24 periodontally healthy adults (controls). Antigens were extracted from Actinomyces actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum and used to set up specific enzyme-linked immunosorbent assay (ELISA) tests to assess IgA and IgG levels to these microorganisms in the fluids collected.
RESULTS
The crevicular fluid of periodontitis patients contained significantly higher levels of IgG to the 4 microorganisms tested than that of controls (P < 10(-6) for all comparisons). IgA levels to the 4 bacteria were statistically significantly much higher in control crevicular fluid (P < 10(-7) for all comparisons). Controls also had statistically significantly higher levels of specific salivary IgA than patients (P < 0.02 for all comparisons).
CONCLUSIONS
These data support the potentially protective role of specific IgA directed to oral microorganisms involved in the onset and development of periodontal disease.
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