Risk Factors for Ebola Exposure in Health Care Workers in Boende, Tshuapa Province, Democratic Republic of the Congo.
Risk Factors for Ebola Exposure in Health Care Workers in Boende, Tshuapa Province, Democratic Republic of the Congo.
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DOI：
10.1093/infdis/jiaa747
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发表时间：
2022-09-04
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影响因子：
--
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与普通人群相比，卫生保健工作者（HCW）在疫情期间更有可能接触埃博拉病毒（EBOV），因为他们与患者有密切的身体接触，并可能接触传染性液体。然而，并非所有人都会生病。尽管有亚临床和少症状性埃博拉病毒病（EVD）的证据，但患病率和相关风险因素仍然未知。我们在刚果民主共和国Tshuapa省的Bogaly进行了HCW血清学调查。使用市售ELISA试剂盒测量人抗EBOV糖蛋白IgG滴度。我们使用单变量和多变量logistic回归评估了抗EBOV IgG血清反应性（定义为≥2.5单位/mL）与风险因素之间的相关性。敏感性分析探索了更保守的截止值，>5单位/mL。总体而言，22.5%的HCW对EBOV具有血清反应性。在多变量分析中，在与确诊、可能或疑似EVD病例互动时使用任何形式的个人防护设备与血清反应性呈负相关（校正比值比，0.23; 95%置信区间，0.07 - 0.73）。我们的研究结果表明HCW中EBOV的高暴露，并为无症状或症状轻微的EVD提供了额外的证据。应进行进一步的研究，以确定进一步传播的可能性，以及血清反应性是否与免疫力有关。我们的研究结果表明HCW中EBOV的高暴露，并为无症状或症状轻微的EVD提供了额外的证据。应进行进一步的研究，以确定进一步传播的可能性，以及血清反应性是否与免疫力有关。
Health care workers (HCW) are more likely to be exposed to Ebola virus (EBOV) during an outbreak compared to people in the general population due to close physical contact with patients and potential exposure to infectious fluids. However, not all will fall ill. Despite evidence of subclinical and paucisymptomatic Ebola virus disease (EVD), prevalence and associated risk factors remain unknown. We conducted a serosurvey among HCW in Boende, Tshuapa Province, Democratic Republic of Congo. Human anti-EBOV glycoprotein IgG titers were measured using a commercially available ELISA kit. We assessed associations between anti-EBOV IgG seroreactivity, defined as ≥2.5 units/mL, and risk factors using univariable and multivariable logistic regression. Sensitivity analyses explored a more conservative cutoff, >5 units/mL. Overall, 22.5% of HCWs were seroreactive for EBOV. In multivariable analyses, using any form of personal protective equipment when interacting with a confirmed, probable, or suspect EVD case was negatively associated with seroreactivity (adjusted odds ratio, 0.23; 95% confidence interval, .07–.73). Our results suggest high exposure to EBOV among HCWs and provide additional evidence for asymptomatic or minimally symptomatic EVD. Further studies should be conducted to determine the probability of onward transmission and if seroreactivity is associated with immunity. Our results suggest high exposure to EBOV among HCWs and provide additional evidence for asymptomatic or minimally symptomatic EVD. Further studies should be conducted to determine the probability of onward transmission and if seroreactivity is associated with immunity.
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DOI：
10.1016/s0140-6736(16)32621-6
发表时间：
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期刊：
Lancet (London, England)
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