Variability in blood oxygen level dependent (BOLD) signal in patients with stroke-induced and primary progressive aphasia.
Variability in blood oxygen level dependent (BOLD) signal in patients with stroke-induced and primary progressive aphasia.
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DOI：
10.1016/j.nicl.2015.03.014
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发表时间：
2015
影响因子：
4.2
通讯作者：
Rapcsak, S. Z.
中科院分区：
文献类型：
--
作者：
Bonakdarpour, B.;Beeson, P. M.;DeMarco, A. T.;Rapcsak, S. Z.
关键词：
虽然功能磁共振成像越来越多地用于评估失语症患者的语言相关的大脑激活，很少有研究探讨了血流动力学反应功能（HRF）的病灶周围，和对侧的大脑区域。此外，HRF异常与其他变量（如病变大小和失语症严重程度）之间的关系尚未探讨。本研究的目的是探讨脑卒中失语症（SA）患者语言相关神经激活过程中HRF信号的变化。我们还检查了非血管性失语症患者的HRF状态，即原发性进行性失语症（PPA）。5名右利手SA患者、3名PPA患者和5名健康个体参与了该研究。结构损伤用T1加权MR图像量化。功能性MR成像采用长期试验事件相关设计和公开命名任务，以测量BOLD信号达到峰值的时间（TTP）和信号变化百分比（ΔS）。在SA患者中，与健康参与者和PPA患者相比，参与命名的左半球区域的平均HRF TTP显著延迟。然而，SA患者的ΔS与其他两组相比无差异。SA患者左半球命名网络的HRF TTP延迟与病变大小相关，与整体语言功能呈负相关。在命名网络的右半球同源物或左右枕叶控制区中，三组的HRF TTP和ΔS没有显著差异。PPA患者的HRF模式正常。我们的研究结果表明，异常的任务相关的HRF主要是发现在左半球的语言网络的SA患者和提高的可能性，异常的生理结构损伤叠加可能有助于临床缺陷。需要对年龄匹配的健康个体、SA和PPA患者进行更大样本的随访调查，以进一步证实和扩展我们的发现。血流动力学达峰时间（TTP）在卒中失语症（SA）中显著延迟。原发性进行性失语患者的TTP与病灶大小呈正相关，而SA患者的TTP与病灶大小呈正相关。SA患者TTP与整体语言功能呈负相关。
Although fMRI is increasingly used to assess language-related brain activation in patients with aphasia, few studies have examined the hemodynamic response function (HRF) in perilesional, and contralesional areas of the brain. In addition, the relationship between HRF abnormalities and other variables such as lesion size and severity of aphasia has not been explored. The objective of this study was to investigate changes in HRF signal during language-related neural activation in patients with stroke-induced aphasia (SA). We also examined the status of the HRF in patients with aphasia due to nonvascular etiology, namely, primary progressive aphasia (PPA). Five right handed SA patients, three PPA patients, and five healthy individuals participated in the study. Structural damage was quantified with T1-weighted MR images. Functional MR imaging was performed with long trial event-related design and an overt naming task to measure BOLD signal time to peak (TTP) and percent signal change (ΔS). In SA patients, the average HRF TTP was significantly delayed in the left hemisphere regions involved in naming compared to healthy participants and PPA patients. However, ΔS was not different in SA patients compared to the other two groups. Delay in HRF TTP in the left hemisphere naming network of SA patients was correlated with lesion size and showed a negative correlation with global language function. There were no significant differences in the HRF TTP and ΔS in the right hemisphere homologues of the naming network or in the left and the right occipital control regions across the three groups. In PPA patients, HRF had a normal pattern. Our results indicate that abnormal task-related HRF is primarily found in the left hemisphere language network of SA patients and raise the possibility that abnormal physiology superimposed on structural damage may contribute to the clinical deficit. Follow-up investigations in a larger sample of age-matched healthy individuals, SA, and PPA patients will be needed to further confirm and extend our findings. Hemodynamic time to peak (TTP) was significantly delayed in stroke aphasics (SA). In primary progressive aphasics no significant hemodynamic change was found. In SA patients, TTP had positive correlation with lesion size. In SA patients, TTP had negative correlation with global language function.
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影响因子：
2.6
作者：
Thompson CK;den Ouden DB;Bonakdarpour B;Garibaldi K;Parrish TB
通讯作者：
Parrish TB
DOI：
10.1016/j.cortex.2012.03.001
发表时间：
2013-03
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Baldo JV;Arévalo A;Patterson JP;Dronkers NF
通讯作者：
Dronkers NF
影响因子：
5.7
作者：
Andersen, Sarah M.;Rapcsak, Steven Z.;Beeson, Pelagie M.
通讯作者：
Beeson, Pelagie M.
影响因子：
5.7
作者：
Bonakdarpour, B.;Parrish, T. B.;Thompson, C. K.
通讯作者：
Thompson, C. K.
影响因子：
8.3
作者：
Peck, KK;Moore, AB;Briggs, RW
通讯作者：
Briggs, RW