Adipokine genes and prostate cancer risk.
Adipokine genes and prostate cancer risk.
复制标题
DOI：
10.1002/ijc.24043
复制
发表时间：
2009-02-15
影响因子：
6.4
通讯作者：
Gunter, Marc J.
中科院分区：
文献类型：
--
作者：
Moore, Steven C.;Leitzmann, Michael F.;Albanes, Demetrius;Weinstein, Stephanie J.;Snyder, Kirk;Virtamo, Jarmo;Ahn, Jiyoung;Mayne, Susan T.;Yu, Herbert;Peters, Ulrike;Gunter, Marc J.
肥胖和脂肪细胞衍生的细胞因子与前列腺癌的发生有关。然而，脂肪因子基因变异与前列腺癌风险的关系还没有得到彻底的研究。因此，我们在一项嵌套在一大批芬兰男性队列中的病例对照研究中，研究了IL6、LEP、LEPR、肿瘤坏死因子和ADIPOQ基因的常见变异与前列腺癌的关系。研究样本包括1,053例前列腺癌患者，平均随访11年，另有1,053名在年龄、干预组和基线抽血日期方面与病例匹配的对照组。使用Logistic回归对前列腺癌的相对风险进行建模。我们还在196名对照组中检测了与血清胰岛素、IGF-1和IGF-1：IGFBP-3相关的基因型别。LEP基因潜在调控区的三个基因座(−14858A>；G、−13973A>；C、−13736C>；A)的变异等位基因使前列腺癌的风险显著降低20%。例如，在−14858A&G基因座，A等位基因杂合子和纯合子患前列腺癌的优势比(OR)分别为0.76(95%可信区间[95%CI]=0.62，0.93)和0.79(95%CI=0.6，1.04)。13288G>；A与GG基因型相比，AA基因型与前列腺癌风险增加相关(OR=1.29；95%CI，0.99，1.67；P-趋势=0.05)。IL6、LEPR、肿瘤坏死因子和ADIPOQ基因的多态与前列腺癌无关。LEP基因中的等位基因变异与前列腺癌风险相关，支持瘦素在前列腺癌发生中的作用。
Adiposity and adipocyte-derived cytokines have been implicated in prostate carcinogenesis. However, the relationship of adipokine gene variants with prostate cancer risk has not been thoroughly investigated. We therefore examined common variants of the IL6, LEP, LEPR, TNF, and ADIPOQ genes in relation to prostate cancer in a case-control study nested within a large cohort of Finnish men. The study sample consisted of 1,053 cases of prostate cancer, diagnosed over an average 11 years of follow up, and 1,053 controls matched to the cases on age, intervention group, and date of baseline blood draw. Logistic regression was used to model the relative odds of prostate cancer. We also examined genotypes in relation to serum insulin, IGF-1, and IGF-1:IGFBP-3 among 196 controls. Variant alleles at three loci (−14858A>G, −13973A>C, −13736C>A) in a potential regulatory region of the LEP gene conferred a statistically significant 20% reduced risk of prostate cancer. For example, at the −14858A>G locus, heterozygotes and homozygotes for the A allele had an odds ratio (OR) of prostate cancer of 0.76 (95% confidence interval [95% CI]= 0.62, 0.93) and 0.79 (95% CI = 0.60, 1.04), respectively. At 13288G>A, relative to the GG genotype, the AA genotype was associated with a suggestive increased risk of prostate cancer (OR = 1.29; 95% CI, 0.99,1.67; P-trend = 0.05). Polymorphisms in the IL6, LEPR, TNF, and ADIPOQ genes were not associated with prostate cancer. Allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis.
登录
查看更多内容
影响因子：
64.8
作者：
Frazer, Kelly A.;Ballinger, Dennis G.;Cox, David R.;Hinds, David A.;Stuve, Laura L.;Gibbs, Richard A.;Belmont, John W.;Boudreau, Andrew;Hardenbol, Paul;Leal, Suzanne M.;Pasternak, Shiran;Wheeler, David A.;Willis, Thomas D.;Yu, Fuli;Yang, Huanming;Zeng, Changqing;Gao, Yang;Hu, Haoran;Hu, Weitao;Li, Chaohua;Lin, Wei;Liu, Siqi;Pan, Hao;Tang, Xiaoli;Wang, Jian;Wang, Wei;Yu, Jun;Zhang, Bo;Zhang, Qingrun;Zhao, Hongbin;Zhao, Hui;Zhou, Jun;Gabriel, Stacey B.;Barry, Rachel;Blumenstiel, Brendan;Camargo, Amy;Defelice, Matthew;Faggart, Maura;Goyette, Mary;Gupta, Supriya;Moore, Jamie;Nguyen, Huy;Onofrio, Robert C.;Parkin, Melissa;Roy, Jessica;Stahl, Erich;Winchester, Ellen;Ziaugra, Liuda;Altshuler, David;Shen, Yan;Yao, Zhijian;Huang, Wei;Chu, Xun;He, Yungang;Jin, Li;Liu, Yangfan;Shen, Yayun;Sun, Weiwei;Wang, Haifeng;Wang, Yi;Wang, Ying;Xiong, Xiaoyan;Xu, Liang;Waye, Mary M. Y.;Tsui, Stephen K. W.;Wong, J. Tze-Fei;Galver, Luana M.;Fan, Jian-Bing;Gunderson, Kevin;Murray, Sarah S.;Oliphant, Arnold R.;Chee, Mark S.;Montpetit, Alexandre;Chagnon, Fanny;Ferretti, Vincent;Leboeuf, Martin;Olivier, Jean-Franccois;Phillips, Michael S.;Roumy, Stephanie;Sallee, Clementine;Verner, Andrei;Hudson, Thomas J.;Kwok, Pui-Yan;Cai, Dongmei;Koboldt, Daniel C.;Miller, Raymond D.;Pawlikowska, Ludmila;Taillon-Miller, Patricia;Xiao, Ming;Tsui, Lap-Chee;Mak, William;Song, You Qiang;Tam, Paul K. H.;Nakamura, Yusuke;Kawaguchi, Takahisa;Kitamoto, Takuya;Morizono, Takashi;Nagashima, Atsushi;Ohnishi, Yozo;Sekine, Akihiro;Tanaka, Toshihiro;Tsunoda, Tatsuhiko;Deloukas, Panos;Bird, Christine P.;Delgado, Marcos;Dermitzakis, Emmanouil T.;Gwilliam, Rhian;Hunt, Sarah;Morrison, Jonathan;Powell, Don;Stranger, Barbara E.;Whittaker, Pamela;Bentley, David R.;Daly, Mark J.;de Bakker, Paul I. W.;Barrett, Jeff;Chretien, Yves R.;Maller, Julian;McCarroll, Steve;Patterson, Nick;Pe'er, Itsik;Price, Alkes;Purcell, Shaun;Richter, Daniel J.;Sabeti, Pardis;Saxena, Richa;Schaffner, Stephen F.;Sham, Pak C.;Varilly, Patrick;Altshuler, David;Stein, Lincoln D.;Krishnan, Lalitha;Smith, Albert Vernon;Tello-Ruiz, Marcela K.;Thorisson, Gudmundur A.;Chakravarti, Aravinda;Chen, Peter E.;Cutler, David J.;Kashuk, Carl S.;Lin, Shin;Abecasis, Goncalo R.;Guan, Weihua;Li, Yun;Munro, Heather M.;Qin, Zhaohui Steve;Thomas, Daryl J.;McVean, Gilean;Auton, Adam;Bottolo, Leonardo;Cardin, Niall;Eyheramendy, Susana;Freeman, Colin;Marchini, Jonathan;Myers, Simon;Spencer, Chris;Stephens, Matthew;Donnelly, Peter;Cardon, Lon R.;Clarke, Geraldine;Evans, David M.;Morris, Andrew P.;Weir, Bruce S.;Tsunoda, Tatsuhiko;Johnson, Todd A.;Mullikin, James C.;Sherry, Stephen T.;Feolo, Michael;Skol, Andrew
通讯作者：
Skol, Andrew
影响因子：
3.8
作者：
Kaplan, Robert C.;Ho, Gloria Y. F.;Anastos, Kathryn
通讯作者：
Anastos, Kathryn
影响因子：
10.3
作者：
Hsing, AW;Chua, S;Stanczyk, FZ
通讯作者：
Stanczyk, FZ
影响因子：
4.9
作者：
Hager, J;Clement, K;Froguel, P
通讯作者：
Froguel, P
影响因子：
1.9
作者：
Li, WD;Reed, DR;Price, RA
通讯作者：
Price, RA