Changes in early alveolar particle clearance due to single and repeated nitrogen dioxide exposures in the rabbit.
Changes in early alveolar particle clearance due to single and repeated nitrogen dioxide exposures in the rabbit.
复制标题
由于兔子单次和重复接触二氧化氮而导致早期肺泡颗粒清除率的变化。
DOI：
10.1080/15287398609530925
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Schlesinger,RB
中科院分区：
文献类型：
--
作者：
Vollmuth,TA;Driscoll,KE;Schlesinger,RB
To better understand the potential health risks associated with short‐term NO2exposures, a study was conducted to examine the effects of single and repeated NO2exposures on the clearance of inert tracer particles from the alveolar region of rabbit lungs. Single 2‐h exposures to 0.3, 1.0, 3.0, and 10.0 ppm produced a concentration‐related acceleration in alveolar particle clearance, which resulted in greater particle removal when compared to control. The greatest response was produced at the lower NO2levels, where as much as 40% more particles were cleared when compared to control. Fewer particles were cleared following a 10.0‐ppm NO2exposure when compared to the lower NO2levels, and there were indications from the clearance pattern that the higher level was beginning to slow clearance, although an actual retardation was not found. Repeated 14‐d exposures (2 hid) to 1.0 or 10.0 ppm NO2produced a response similar to a single exposure at the same concentration, suggesting a certain degree of adaptation was produced after the initial exposures. Possible mechanisms for these differences in clearance patterns are discussed. The results of this study demonstrated altered alveolar clearance following short‐term NO2exposure at environmentally relevant concentrations; changes in this important host defense mechanism may be indicative of some underlying pathologic condition.
登录
查看更多内容
DOI：
10.1016/0272-0590(85)90091-0
发表时间：
1985
期刊：
Fundamental and applied toxicology : official journal of the Society of Toxicology
影响因子：
--
作者：
Schlesinger,RB
通讯作者：
Schlesinger,RB
SO2 对大鼠肺清除 TiO2 颗粒的影响。
DOI：
10.1080/0002889738506843
发表时间：
1973
期刊：
American Industrial Hygiene Association journal
影响因子：
--
作者：
J. Ferin;L. J. Leach
通讯作者：
L. J. Leach
暴露于氧化铁气溶胶的小鼠肺部的清除途径
DOI：
10.1002/ar.1091810304
发表时间：
1975
期刊：
The Anatomical Record
影响因子：
--
作者：
S. Sorokin;J. Brain
通讯作者：
J. Brain
肺部对低水平二氧化氮的早期反应。
DOI：
--
发表时间：
1972
期刊：
Archives of Environmental Health An International Journal
影响因子：
--
作者：
R. J. Stephens;G. Freeman;M. J. Evans
通讯作者：
M. J. Evans
暴露于 NO2 后大鼠肺中肺泡巨噬细胞的细胞分裂。
影响因子：
6
作者：
M. J. Evans;L. J. Cabral;R. J. Stephens;G. Freeman
通讯作者：
G. Freeman