The rectal mucosal immune environment and HIV susceptibility among young men who have sex with men.
The rectal mucosal immune environment and HIV susceptibility among young men who have sex with men.
复制标题
DOI：
10.3389/fimmu.2022.972170
复制
发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
在美国，年轻男男性行为者 (YMSM) 是感染艾滋病毒的高危人群，尽管报告的性活动率与老年成年男男性行为者 (AMSM) 相似。与 AMSM 相比，YMSM 中 HIV 感染率的增加可能部分归因于直肠粘膜 (RM) 免疫环境的差异，这些差异与首次性行为较早和终生接触肛交的时间较少有关。使用离体外植体 HIV 攻击模型，我们发现与 AMSM 相比，YMSM 的直肠组织在病毒复制峰值时间点支持更高水平的 p24。在 YMSM 中，RM 的特点是 CD4+ T 细胞增殖增加，以及组织驻留 CD8+ T 细胞和产生促炎细胞因子的 CD4+ 和 CD8+ T 细胞频率较低。此外，YMSM 的微生物组组成还丰富了以前与 HIV 感染风险相关的厌氧类群，包括普氏菌属、消化链球菌属和嗜消化菌属。这些独特的免疫学和微生物组特征被发现与直肠外植体离体攻击后较高的 HIV 复制有关，表明 YMSM 的 RM 微环境可能特别有利于 HIV 感染。
Young men who have sex with men (YMSM) represent a particularly high-risk group for HIV acquisition in the US, despite similarly reported rates of sexual activity as older, adult MSM (AMSM). Increased rates of HIV infection among YMSM compared to AMSM could be partially attributable to differences within the rectal mucosal (RM) immune environment associated with earlier sexual debut and less lifetime exposure to receptive anal intercourse. Using an ex vivo explant HIV challenge model, we found that rectal tissues from YMSM supported higher levels of p24 at peak viral replication timepoints compared to AMSM. Among YMSM, the RM was characterized by increased CD4+ T cell proliferation, as well as lower frequencies of tissue resident CD8+ T cells and pro-inflammatory cytokine producing CD4+ and CD8+ T cells. In addition, the microbiome composition of YMSM was enriched for anaerobic taxa that have previously been associated with HIV acquisition risk, including Prevotella, Peptostreptococcus, and Peptoniphilus. These distinct immunologic and microbiome characteristics were found to be associated with higher HIV replication following ex vivo challenge of rectal explants, suggesting the RM microenvironment of YMSM may be uniquely conducive to HIV infection.
登录
查看更多内容
影响因子：
14.9
作者：
Klindworth A;Pruesse E;Schweer T;Peplies J;Quast C;Horn M;Glöckner FO
通讯作者：
Glöckner FO
DOI：
10.4049/jimmunol.1203100
发表时间：
2013-02-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kamada N;Núñez G
通讯作者：
Núñez G
影响因子：
5.4
作者：
Maric, Danijela;Grimm, Wesley A.;Hope, Thomas J.
通讯作者：
Hope, Thomas J.
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
4.4
作者：
Antons, Amanda K.;Wang, Rui;Unutmaz, Derya
通讯作者：
Unutmaz, Derya