Disruptions of cortico-kinematic interactions in Parkinson’s disease
Disruptions of cortico-kinematic interactions in Parkinson’s disease
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帕金森病中皮质运动相互作用的破坏
DOI：
10.1016/j.bbr.2021.113153
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发表时间：
2021
影响因子：
2.7
通讯作者：
Shahriari, Y.
中科院分区：
文献类型：
--
作者：
McLinden, J.;Deligani, R.J.;Abtahi, M.R.;Akbar, U.;Mankodiya, K.;Shahriari, Y.
帕金森病（PD）运动学特征所反映的运动症状的皮质作用知之甚少。在这项研究中，我们的目的是探讨PD如何影响皮质运动的相互作用。在一组自定节奏的手指敲击任务中，记录了七名健康参与者和八名诊断患有PD的参与者的脑电图（EEG）和运动学数据。在α（8 - 14 Hz）、低-β（14 - 20 Hz）和高-β（20 - 35 Hz）频段上比较了两组之间的事件相关去激活（ERD），以研究与运动相关的皮质活动的组间差异。提取平均运动学峰值幅度和平均振幅以及样本熵（SaEn）（信号复杂性的度量）作为组间比较的变量。这些变量进一步与每个频带的平均EEG功率相关，以建立皮质运动功能和运动学运动输出之间的组内相互作用。在健康组中，高频段功率与平均运动峰值潜伏期和信号复杂度相关，而在PD组中未发现相关性。此外，健康组在宽频带中表现出比PD参与者更强的ERD。我们的研究结果表明，在健康人群中，皮层高频功率与手指敲击潜伏期和运动复杂性分级，但这种关系在PD中受损。这些见解可能有助于进一步增强我们对健康运动中皮质B波段振荡的作用以及PD中这种关系可能中断的理解。这些结果可以为治疗和治疗应用提供进一步的指导，并可能建立帕金森病的皮质生物标志物。
The cortical role of the motor symptoms reflected by kinematic characteristics in Parkinson’s disease (PD) is poorly understood. In this study, we aim to explore how PD affects cortico-kinematic interactions. Electroencephalographic (EEG) and kinematic data were recorded from seven healthy participants and eight participants diagnosed with PD during a set of self-paced finger tapping tasks. Event-related desynchronization (ERD) was compared between groups in the α (8−14 Hz), low-ß (14−20 Hz), and high-ß (20−35 Hz) frequency bands to investigate between-group differences in the cortical activities associated with movement. Average kinematic peak amplitudes and latencies were extracted alongside Sample Entropy (SaEn), a measure of signal complexity, as variables for comparison between groups. These variables were further correlated with average EEG power in each frequency band to establish within-group interactions between cortical motor functions and kinematic motor output. High ß-band power correlated with mean kinematic peak latency and signal complexity in the healthy group, while no correlation was found in the PD group. Also, the healthy group demonstrated stronger ERD in the broad ß-band than the PD participants. Our results suggest that cortical ß-band power in healthy populations is graded to finger tapping latency and complexity of movement, but this relationship is impaired in PD. These insights could help further enhance our understanding of the role of cortical ß-band oscillations in healthy movement and the possible disruption of that relationship in PD. These outcomes can provide further directions for treatment and therapeutic applications and potentially establish cortical biomarkers of Parkinson’s disease.
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帕金森病模型中皮质β功率和步态速度之间的相关性受到抑制，但通过治疗性深部脑刺激可以恢复
影响因子：
6.1
作者：
Christian A. Polar;Rahul Gupta;M. Lehmkuhle;A. Dorval
通讯作者：
A. Dorval
影响因子：
4.9
作者：
Stuart S;Vitorio R;Morris R;Martini DN;Fino PC;Mancini M
通讯作者：
Mancini M
影响因子：
6.1
作者：
Tinkhauser G;Torrecillos F;Duclos Y;Tan H;Pogosyan A;Fischer P;Carron R;Welter ML;Karachi C;Vandenberghe W;Nuttin B;Witjas T;Régis J;Azulay JP;Eusebio A;Brown P
通讯作者：
Brown P
影响因子：
11.7
作者：
Breanna E. Studenka;A. Raikes
通讯作者：
A. Raikes
DOI：
10.1109/tnsre.2018.2868140
发表时间：
2018-10-01
影响因子：
4.9
作者：
Cheng, Fang-Yu;Yang, Yea-Ru;Wang, Ray-Yau
通讯作者：
Wang, Ray-Yau