Beta burst coupling across the motor circuit in Parkinson's disease.
Beta burst coupling across the motor circuit in Parkinson's disease.
复制标题
DOI：
10.1016/j.nbd.2018.06.007
复制
发表时间：
2018-09
影响因子：
6.1
通讯作者：
Brown P
中科院分区：
文献类型：
--
作者：
Tinkhauser G;Torrecillos F;Duclos Y;Tan H;Pogosyan A;Fischer P;Carron R;Welter ML;Karachi C;Vandenberghe W;Nuttin B;Witjas T;Régis J;Azulay JP;Eusebio A;Brown P
β频段（13-35 Hz）的夸大活动是帕金森病（PD）患者基底神经节信号的标志。然而，β活动并不是不断升高，而是突然爆发。在以前的工作中，我们表明，β爆发维持的时间越长，丘脑底核内的振荡同步性就越大，这被认为限制了局部回路的信息编码能力。因此，较长爆发的较高发生率与临床损伤正相关，而对于较短的生理爆发则相反。在这里，我们测试的假设，β爆发不仅表明本地同步内的神经元，而且相位耦合整个运动网络，因此需要更大的限制，PD患者的信息编码能力。局部场电位从丘脑底核和EEG运动皮层区域记录在9个PD患者术后暂时铅外部化后，脑深部电刺激和左旋多巴的隔夜撤出。Beta爆发被定义为超过信号幅度第75百分位数的周期，并且使用两个不同的测量来考虑爆发之间的耦合，首先是重叠%（%OVL）作为幅度耦合的特征，其次是相位同步指数（PSI）来测量区域之间的相位耦合。与独立的情况相比，大脑皮层和皮质之间以及左侧和右侧大脑皮层之间的%OVL高于预期。同样，PSI在爆发期间高于非爆发期间。此外，与短爆发相比，长爆发的%OVL更大。我们的研究结果支持这一假设，即β爆发涉及在基底神经节皮质网络的结构之间的长程耦合。这种影响在长时间β爆发期间比短时间β爆发期间更大。因此，我们认为基底神经节-皮层回路中多个结构的耦合同时升高进一步限制了信息编码能力，并可能对运动障碍产生进一步影响。
Exaggerated activity in the beta band (13–35 Hz) is a hallmark of basal ganglia signals in patients with Parkinson's disease (PD). Beta activity however is not constantly elevated, but comes in bursts. In previous work we showed that the longer beta bursts are maintained, the more the oscillatory synchronisation within the subthalamic nucleus (STN) increases, which is posited to limit the information coding capacity of local circuits. Accordingly, a higher incidence of longer bursts correlates positively with clinical impairment, while the opposite is true for short, more physiological bursts. Here, we test the hypothesis that beta bursts not only indicate local synchronisation within the STN, but also phasic coupling across the motor network and hence entail an even greater restriction of information coding capacity in patients with PD. Local field potentials from the subthalamic nucleus and EEG over the motor cortex area were recorded in nine PD patients after temporary lead externalization after surgery for deep brain stimulation and overnight withdrawal of levodopa. Beta bursts were defined as periods exceeding the 75th percentile of signal amplitude and the coupling between bursts was considered using two distinct measurements, first the % overlapping (%OVL) as a feature of the amplitude coupling and secondly the phase synchrony index (PSI) to measure the phase coupling between regions. %OVL between STN and cortex and between the left and the right STN was higher than expected between the regions than if they had been independent. Similarly, PSI was higher during bursts as opposed to non-bursts periods. In addition, %OVL was greater for long compared to short bursts. Our results support the hypothesis that beta bursts involve long-range coupling between structures in the basal ganglia-cortical network. The impact of this is greater during long as opposed to short duration beta bursts. Accordingly, we posit that episodes of simultaneously elevated coupling across multiple structures in the basal ganglia-cortical circuit further limit information coding capacity and may have further impact upon motor impairment.
登录
查看更多内容
影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
晚期帕金森病的自适应深脑刺激。
影响因子：
11.2
作者：
Little, Simon;Pogosyan, Alex;Neal, Spencer;Zavala, Baltazar;Zrinzo, Ludvic;Hariz, Marwan;Foltynie, Thomas;Limousin, Patricia;Ashkan, Keyoumars;FitzGerald, James;Green, Alexander L.;Aziz, Tipu Z.;Brown, Peter
通讯作者：
Brown, Peter
影响因子：
3.4
作者：
Kühn, AA;Kupsch, A;Brown, P
通讯作者：
Brown, P
DOI：
10.1073/pnas.1517629112
发表时间：
2015-11-03
影响因子：
11.1
作者：
Feingold, Joseph;Gibson, Daniel J.;Graybiel, Ann M.
通讯作者：
Graybiel, Ann M.
影响因子：
5.3
作者：
Chen, Chiung Chu;Hsu, Yi Ting;Brown, Peter
通讯作者：
Brown, Peter