Correlation between cortical beta power and gait speed is suppressed in a parkinsonian model, but restored by therapeutic deep brain stimulation
Correlation between cortical beta power and gait speed is suppressed in a parkinsonian model, but restored by therapeutic deep brain stimulation
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帕金森病模型中皮质β功率和步态速度之间的相关性受到抑制，但通过治疗性深部脑刺激可以恢复
DOI：
10.1016/j.nbd.2018.05.013
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发表时间：
2018
影响因子：
6.1
通讯作者：
A. Dorval
中科院分区：
文献类型：
--
作者：
Christian A. Polar;Rahul Gupta;M. Lehmkuhle;A. Dorval
帕金森病（PD）患者的运动皮层和丘脑底核（STN）在~12-35 Hz β频率范围内表现出异常高水平的电生理振荡。最近的研究表明，在健康状况下，β部分地被结转以调节未来的运动状态，这表明当在短时间内发生一系列运动时，例如在快速步态期间，稳态β功率较低。然而，这种β功率和运动状态之间的关系是否在帕金森病发作后或有效治疗后持续存在尚不清楚。使用6-羟基多巴胺（6-OHDA）大鼠PD模型和定制的行为和神经生理记录系统，我们的目的是阐明更好地了解皮质β功率和PD症状的机制。除了升高的β振荡水平，我们发现帕金森病发作伴随着运动强度（量化为步态速度）与皮质β功率的解耦。虽然丘脑底脑深部电刺激（DBS）降低了所有PD动物皮质中β振荡的一般水平，但大脑调节β功率稳态水平（作为运动强度的函数）的能力仅在DBS治疗动物中恢复。我们认为，除了降低皮质β功率的一般水平外，恢复大脑维持这种反向关系的能力对于有效的症状抑制至关重要。
The motor cortex and subthalamic nucleus (STN) of patients with Parkinson's disease (PD) exhibit abnormally high levels of electrophysiological oscillations in the ~12–35 Hz beta-frequency range. Recent studies have shown that beta is partly carried forward to regulate future motor states in the healthy condition, suggesting that steady state beta power is lower when a sequence of movements occurs in a short period of time, such as during fast gait. However, whether this relationship between beta power and motor states persists upon parkinsonian onset or in response to effective therapy is unclear. Using a 6-hydroxy dopamine (6-OHDA) rat model of PD and a custom-built behavioral and neurophysiological recording system, we aimed to elucidate a better understanding of the mechanisms underlying cortical beta power and PD symptoms. In addition to elevated levels of beta oscillations, we show that parkinsonian onset was accompanied by a decoupling of movement intensity — quantified as gait speed — from cortical beta power. Although subthalamic deep brain stimulation (DBS) reduced general levels of beta oscillations in the cortex of all PD animals, the brain's capacity to regulate steady state levels of beta power as a function of movement intensity was only restored in animals with therapeutic DBS. We propose that, in addition to lowering general levels of cortical beta power, restoring the brain's ability to maintain this inverse relationship is critical for effective symptom suppression.
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影响因子：
14.5
作者：
Levy, R;Ashby, P;Dostrovsky, JO
通讯作者：
Dostrovsky, JO
影响因子：
14.5
作者：
Crowell, Andrea L.;Ryapolova-Webb, Elena S.;Starr, Philip A.
通讯作者：
Starr, Philip A.
影响因子：
16.6
作者：
Pape, Anna-Antonia;Siegel, Markus
通讯作者：
Siegel, Markus
帕金森氏病患者的丘脑下β带活性与运动障碍的长期相关性。
DOI：
10.1016/j.clinph.2017.08.028
发表时间：
2017-11
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Neumann WJ;Staub-Bartelt F;Horn A;Schanda J;Schneider GH;Brown P;Kühn AA
通讯作者：
Kühn AA
DOI：
10.1073/pnas.97.4.1867
发表时间：
2000-02-15
影响因子：
11.1
作者：
Kopell, N;Ermentrout, GB;Traub, RD
通讯作者：
Traub, RD