The clock gene PER2 and sleep problems: association with alcohol consumption among Swedish adolescents.
The clock gene PER2 and sleep problems: association with alcohol consumption among Swedish adolescents.
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DOI：
10.3109/03009731003597127
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发表时间：
2010-02
影响因子：
3.4
通讯作者：
Nilsson KW
中科院分区：
文献类型：
--
作者：
Comasco E;Nordquist N;Göktürk C;Aslund C;Hallman J;Oreland L;Nilsson KW
酒精滥用与睡眠问题有关，而睡眠问题通常与昼夜节律紊乱有关。之前的研究分别研究了生物钟基因PER2突变对饮酒和睡眠问题的影响。在这里，我们假设PER2基因的等位基因变异与饮酒和青少年睡眠问题相互作用有关。在2006年的青少年生活和健康调查Västmanland中，瑞典的一个县，包括1254名17-18岁的学生，作为青少年的人口代表性样本。我们在队列中调查了PER2单核苷酸多态性（SNP） 10870 (A/G)，并根据AUDIT-C问卷评估了饮酒情况，并使用包含18个项目的调查问卷评估了睡眠问题。此外，我们对一组重度酗酒女性的PER2单核苷酸多态性10870多态性进行了探索性分析。我们在青春期男孩中发现SNP 10870的显著关联，其中AA基因型，在存在几种和频繁的睡眠问题时，与饮酒增加有关。在青春期女孩中，只有睡眠问题与饮酒有关。在重度酗酒女性中观察到一个不显著的趋势，与对照女性相比，G等位基因在重度酗酒女性组中被过度代表。这些结果表明，在瑞典青春期男孩中，PER2基因变异与饮酒和睡眠问题有关。
Alcohol abuse is associated with sleep problems, which are often linked to circadian rhythm disturbances. Previous studies have separately examined the effects of mutations in the clock gene PER2 on alcohol consumption and sleep problems. Here we hypothesized that an allelic variation in the PER2 gene is associated with alcohol consumption in interaction with sleep problems among adolescents. The Survey of Adolescent Life and Health in Västmanland 2006, a Swedish county, including 1254 students 17–18 years old, was used as a population-representative sample of adolescents. We investigated the PER2 Single Nucleotide polymorphism (SNP) 10870 (A/G) in the cohort together with an assessment of alcohol consumption according to the AUDIT-C questionnaire, and sleep problems using a survey consisting of 18 items. Furthermore, we carried out an exploratory analysis on the PER2 Single Nucleotide Polymorphism 10870 polymorphism in a group of severely alcoholic females. We found a significant association of the SNP 10870 in adolescent boys, where the genotype AA, in the presence of several and frequent sleep problems, was associated with increased alcohol consumption. Among adolescent girls, only sleep problems were related to alcohol consumption. A non-significant trend was observed among the severely alcoholic females, with the G allele being over-represented in the severely alcoholic females group in comparision to the control females. These results indicate that PER2 gene variation is associated with alcohol consumption in interaction with sleep problems among Swedish adolescent boys.
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DOI：
10.1097/01.alc.0000128239.87611.f5
发表时间：
2004-06-01
影响因子：
3.2
作者：
Kokotailo, PK;Egan, J;Fleming, M
通讯作者：
Fleming, M
DOI：
10.1073/pnas.0602006103
发表时间：
2006-05-02
影响因子：
11.1
作者：
Franken, P;Dudley, CA;McKnight, SL
通讯作者：
McKnight, SL
影响因子：
4.7
作者：
Falcón E;McClung CA
通讯作者：
McClung CA
影响因子：
4.7
作者：
Chen, CP;Kuhn, P;Sarkar, DK
通讯作者：
Sarkar, DK
影响因子：
9.2
作者：
Hampp, Gabriele;Ripperger, Juergen A.;Albrecht, Urs
通讯作者：
Albrecht, Urs