Cardiovascular applications of therapeutic ultrasound.

Cardiovascular applications of therapeutic ultrasound.
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DOI:
10.1007/s10840-013-9845-z
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发表时间:
2014-04
影响因子:
1.8
通讯作者:
Matula, Thomas J.
Matula, Thomas J.
中科院分区:
医学4区
文献类型:
--
作者:
Nazer, Babak;Gerstenfeld, Edward P.;Hata, Akiko;Crum, Lawrence A.;Matula, Thomas J.

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超声(美国)在心血管诊断应用中得到了广泛的应用。在典型的诊断使用的幅度和频率下,其对组织的生物力学影响基本上可以忽略不计。然而,这些参数可以被改变,以利用美国的热效应和非热效应来治疗适应症。高强度聚焦超声(HIFU)和体外冲击波治疗(ECWT)是目前已被研究用于治疗心律失常和缺血性心脏病的两种超声治疗方法。在这里,我们回顾了HIFU和ECWT的生物力学效应,它们的潜在治疗机制,以及证明它们的有效性和安全性的临床前和临床研究。此外,我们还讨论了治疗性超声的其他潜在临床应用以及未来需要研究的领域。
Ultrasound (US) has gained widespread use in diagnostic cardiovascular applications. At amplitudes and frequencies typical of diagnostic use, its biomechanical effects on tissue are largely negligible. However, these parameters can be altered to harness US’s thermal and non-thermal effects for therapeutic indications. High-intensity focused ultrasound (HIFU) and extracorporeal shock wave therapy (ECWT) are two therapeutic US modalities which have been investigated for treating cardiac arrhythmias and ischemic heart disease, respectively. Here, we review the biomechanical effects of HIFU and ECWT, their potential therapeutic mechanisms, and pre-clinical and clinical studies demonstrating their efficacy and safety limitations. Furthermore, we discuss other potential clinical applications of therapeutic US and areas in which future research is needed.
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期刊: EUROPACE
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