Impaired fibrinolytic response to exercise in type II diabetes: effects of exercise and physical training.
Impaired fibrinolytic response to exercise in type II diabetes: effects of exercise and physical training.
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II 型糖尿病患者对运动的纤溶反应受损：运动和体能训练的影响。
DOI：
10.1016/0026-0495(88)90148-5
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Ruderman,NB
中科院分区：
文献类型：
--
作者：
Schneider,SH;Kim,HC;Khachadurian,AK;Ruderman,NB
我们研究了运动和体能训练对16名久坐不动的非胰岛素依赖型糖尿病患者凝血参数和纤溶活性的影响，以及9名既往体育锻炼匹配的对照受试者。在休息和30分钟的自行车运动后，在70%至75%的最大摄氧量下，在6周的每周三次体育训练之前和之后测量参数。在非训练状态下，与对照组相比，糖尿病患者的纤溶活性降低（1.26±0.19v2.20±0.34 U， P< 0.3），静息时血浆纤维蛋白原水平（329±21v266±17 mg/dL， P< 0.01）和凝血酶原时间（PT）最大速度（Vmax）（4.9±0.5v2.9±0.5，P< 0.05）升高。活化的部分凝血活素时间（APTT） Vmax（3.6±0.2v2.3±0.5；P< 0.10）明显升高，但差异无统计学意义。两组患者运动后均出现纤溶活性，但糖尿病患者的峰值活性和增量较小。6周的体育锻炼对血浆纤维蛋白原水平没有影响，但显著提高了糖尿病患者静息和运动后APTT Vmax和静息纤维蛋白溶解活性。与正常对照组相比，运动引起的训练后纤维蛋白溶解活性的增加仍然很低。APTT Vmax的变化与血糖控制指标的变化相关。这些发现与运动可能的抗动脉粥样硬化作用的相关性以及运动产生这些作用的机制仍有待确定。
We studied the effects of exercise and physical training on coagulation parameters and fibrinolytic activity in 16 sedentary non-insulin-dependent diabetics and nine control subjects matched for prior physical activity. Parameters were measured at rest and after 30 minutes of bicycle exercise at 70% to 75% of maximal oxygen uptake before and after 6 weeks of thrice-weekly physical training. In the untrained state, fibrinolytic activity was impaired in diabetics compared with controls (1.26 ± 0.19v2.20 ± 0.34 U;P< 0.3), and resting levels of plasma fibrinogen (329 ± 21v266 ± 17 mg/dL;P< .01) and the prothrombin time (PT) maximal velocity (Vmax) (4.9 ± 0.5v2.9 ± 0.5;P< .05) were increased. The activated partial thromboplastin time (APTT) Vmax was also increased but this did not reach statistical significance (3.6 ± 0.2v2.3 ± 0.5;P< 0.10). Activation of fibrinolysis occurred following exercise in both groups but the peak activity and increment were less in diabetics. Physical training for 6 weeks had no effect on plasma fibrinogen levels but significantly improved the resting and postexercise APTT Vmax and resting fibrinolytic activity in diabetics. The exercise-induced increment in fibrinolytic activity following training remained depressed compared with normal controls. The changes in APTT Vmax correlated with changes in the indices of blood glucose control. The relevance of these findings to possible antiatherogenic effects of exercise and the mechanism by which exercise produces these effects remain to be established.
便携式输液泵在接受连续输注抗癌药物的门诊患者中的局限性。
DOI：
--
发表时间：
1979
期刊：
Cancer treatment reports
影响因子：
--
作者：
R. Dorr;C. Trinca;K. Griffith;P. L. Dombrowsky;S. Salmon
通讯作者：
S. Salmon
便携式输液泵在门诊癌症化疗中的应用
影响因子：
6.2
作者：
T. Plasse;T. Ohnuma;H. Bruckner;K. Chamberlain;Terry Mass;J. F. Holland
通讯作者：
J. F. Holland
通过流动输液泵进行癌症化疗
DOI：
--
发表时间：
1983
期刊：
American Journal of Clinical Oncology
影响因子：
--
作者：
J. Lokich;J. Perri;A. Bothe;T. Zipoli;D. Philips;H. Sonneborn;S. Paul;R. Green
通讯作者：
R. Green