Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant Effect of Antioxidant Agents.
Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant Effect of Antioxidant Agents.
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DOI：
10.3390/ijms18102098
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发表时间：
2017-10-05
影响因子：
5.6
通讯作者：
Rubio-Ruiz ME
中科院分区：
文献类型：
--
作者：
Pérez-Torres I;Guarner-Lans V;Rubio-Ruiz ME
还原应激（RS）是氧化应激（OS）的对应物，并且可以响应于将重要的生物氧化还原对（例如NAD+/NADH、NADP+/NADPH和GSH/GSSG）的氧化还原平衡转移到更还原状态的条件而发生。抗氧化酶系统的过度表达导致过量的还原当量，其可以消耗反应性氧化物质，将细胞驱动至RS。建立了一种反馈调节机制，其中慢性RS诱导OS，OS反过来又刺激RS。过量的还原当量可调节细胞信号传导途径，改变转录活性，诱导蛋白质中二硫键形成的改变，降低线粒体功能，降低细胞代谢，从而促进氧化还原敏感性转录因子NF-κB参与的一些疾病的发展。在这里，我们描述了与RS相关的炎症性疾病，其中发现了延迟折叠、无序转运、氧化失败和聚集，其中一些疾病是聚集蛋白心肌病、肥厚型心肌病、肌营养不良、肺动脉高压、类风湿性关节炎、阿尔茨海默病和代谢综合征等。此外，长期食用抗氧化剂补充剂，如维生素和/或类黄酮，可能具有促氧化作用，可能改变氧化还原细胞平衡并导致RS，甚至缩短预期寿命。
Reductive stress (RS) is the counterpart oxidative stress (OS), and can occur in response to conditions that shift the redox balance of important biological redox couples, such as the NAD+/NADH, NADP+/NADPH, and GSH/GSSG, to a more reducing state. Overexpression of antioxidant enzymatic systems leads to excess reducing equivalents that can deplete reactive oxidative species, driving the cells to RS. A feedback regulation is established in which chronic RS induces OS, which in turn, stimulates again RS. Excess reducing equivalents may regulate cellular signaling pathways, modify transcriptional activity, induce alterations in the formation of disulfide bonds in proteins, reduce mitochondrial function, decrease cellular metabolism, and thus, contribute to the development of some diseases in which NF-κB, a redox-sensitive transcription factor, participates. Here, we described the diseases in which an inflammatory condition is associated to RS, and where delayed folding, disordered transport, failed oxidation, and aggregation are found. Some of these diseases are aggregation protein cardiomyopathy, hypertrophic cardiomyopathy, muscular dystrophy, pulmonary hypertension, rheumatoid arthritis, Alzheimer’s disease, and metabolic syndrome, among others. Moreover, chronic consumption of antioxidant supplements, such as vitamins and/or flavonoids, may have pro-oxidant effects that may alter the redox cellular equilibrium and contribute to RS, even diminishing life expectancy.
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影响因子：
5.9
作者：
Benstoem C;Goetzenich A;Kraemer S;Borosch S;Manzanares W;Hardy G;Stoppe C
通讯作者：
Stoppe C
影响因子：
7.4
作者：
Badia, Mari-Carmen;Giraldo, Esther;Vina, Jose
通讯作者：
Vina, Jose
DOI：
10.1152/ajpheart.00102.2004
发表时间：
2004-09-01
影响因子：
4.8
作者：
Chen, Y;Arrigo, AP;Currie, RW
通讯作者：
Currie, RW
DOI：
10.1152/ajpheart.00903.2011
发表时间：
2012-01-01
影响因子：
4.8
作者：
Christians, Elisabeth S.;Benjamin, Ivor J.
通讯作者：
Benjamin, Ivor J.
影响因子：
4.1
作者：
BOLTON, JL;SEVESTRE, H;THOMPSON, JA
通讯作者：
THOMPSON, JA