Evaluating the Effects of Low Carbohydrate and High Protein Diet on Erectile Function in Rats.
Evaluating the Effects of Low Carbohydrate and High Protein Diet on Erectile Function in Rats.
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DOI：
10.1016/j.esxm.2022.100500
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发表时间：
2022-04
期刊：
影响因子：
2.6
通讯作者：
Kimura, Kazunori
中科院分区：
文献类型：
--
作者：
Kataoka, Tomoya;Hidaka, Junya;Suzuki, Jun;Mori, Taiki;Nakamura, Daigaku;Hotta, Yuji;Sanagawa, Akimasa;Maeda, Yasuhiro;Furukawa-Hibi, Yoko;Kimura, Kazunori
限制饮食中的碳水化合物正在成为当今流行的减肥方法，尽管有报道称，过量摄入低碳水化合物和高蛋白(LCHP)饮食会对心血管功能产生不利影响。目的：探讨低密度脂蛋白对大鼠勃起功能的影响。将48只12周龄大鼠随机分为2组，每组10只，分别饲喂LC HP饲料(LC HP组)和正常饲料(对照组)。采用标准化方法对大鼠进行血液学检查、血压测定、勃起功能测定以及海绵体舒缩反应的评价。所得数据采用双因素方差分析和韦氏t检验进行统计分析。在研究结束时，评估海绵体内压、平均动脉压、内皮功能、一氧化氮(NO)操作的神经功能以及内皮型一氧化氮合酶(ENOS)、神经元型一氧化氮合酶(NNOS)和鞘氨醇-1-磷酸受体1(S1P1)的表达。在4周时，LCHP组的海绵体内压/平均动脉压比显著降低(P<；0.05)。与对照组相比，LCHP组对ACh和EFS的反应显著降低，nNOS mRNA表达减少。基于该动物模型的结果表明，极端碳水化合物限制饮食可能会影响勃起功能。我们的研究发现，LCHP降低了大鼠的勃起功能。这项研究的一大局限是，由于用蛋白质完全取代碳水化合物的极端条件，未来碳水化合物的摄入量将逐渐增加。过度的碳水化合物限制和高蛋白饮食可能导致ED伴血管内皮功能障碍，并通过非手术神经降低海绵体平滑肌的松弛反应。王晓明，李晓波，等.中国社会科学院院士低碳水化合物高蛋白饮食对大鼠勃起功能的影响《性医学》2021年；10：100500。
Carbohydrate restriction in diet is becoming a popular means of losing weight nowadays, although it has been reported that excessive intake of low-carbohydrate and high-protein (LCHP) diet causes an adverse effect on cardiovascular function. To investigate the influence of LCHP on erectile function in rats. A total of 48, 12-week-old rats were divided into 2 groups and either fed a LCHP diet (LCHP group) or a normal diet (Control group). Hematological examination, blood pressure evaluation, erectile function assessments as well as evaluations of the relaxation and contractile responses of corpus cavernosum were carried out in these rats by using standardized methods. Statistical analysis using 2-way ANOVA and Welch's t-test was conducted to examine the obtained data. At the end of the study period, the evaluated outcomes to assess erectile function were intracavernosal pressure , mean arterial pressure , endothelial functions, nitric oxide (NO)-operated nerve functions and the expressions of endothelial nitric oxide synthase (eNOS), neuronal nitric oxide synthase (nNOS), and sphingosine-1-phosphate receptor 1 (S1P1). The intracavernosal pressure / mean arterial pressure ratio was significantly lower in the LCHP group (P < .05) at 4 weeks. Compared to the Control group, the LCHP group exhibited significantly lower responses to ACh and EFS and a decreased nNOS mRNA expression. The results based on this animal model indicate that extreme carbohydrate restricted diet may affect erectile function. Our study identified that LCHP decreased erectile function in rats. A major limitation of this study is, due to the extreme condition of completely replacing carbohydrates with protein, that carbohydrate intake will be gradually increased in the future. Extreme carbohydrate restriction and high protein in diet may cause ED with vascular endothelial dysfunction and a decrease in the relaxation response of the corpus cavernosum smooth muscle via NO-operated nerves. Kataoka T, Hidaka J, Suzuki J, et al. Evaluating the Effects of Low Carbohydrate and High Protein Diet on Erectile Function in Rats. Sex Med 2021;10:100500.
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