Crossing nerve transfer drives sensory input-dependent plasticity for motor recovery after brain injury.
Crossing nerve transfer drives sensory input-dependent plasticity for motor recovery after brain injury.
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交叉神经传递驱动感觉输入——依赖可塑性以促进脑损伤后的运动恢复
DOI：
10.1126/sciadv.abn5899
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发表时间：
2022-09-02
期刊：
影响因子：
13.6
通讯作者：
中科院分区：
文献类型：
--
作者：
在中枢神经系统损伤后恢复肢体运动仍然是一个巨大的挑战。近年来的研究证明，交叉神经移位手术可以重建对侧皮层与瘫痪手臂之间的生理连接，以弥补脑损伤后失去的功能。然而，这种手术介导运动恢复的神经机制仍不清楚。在这里，使用临床小鼠模型，我们表明，这种手术可以通过诱导皮质重映射和促进皮质脊髓束发芽来恢复单侧皮质损伤的成年小鼠的熟练前肢功能。在重建同侧下行通路后，切除人工重建的周围神经并不影响运动的改善。此外，保留的感觉传入，但不是运动传出，转移的神经足以诱导大脑重新映射，促进运动恢复。因此，我们的研究结果表明，手术重建的感觉输入触发神经可塑性，加速运动恢复，这提供了一种治疗中枢神经系统损伤的方法。重建感觉输入对于诱导内在神经可塑性以恢复脑损伤后的熟练运动功能至关重要。
Restoring limb movements after central nervous system injury remains a substantial challenge. Recent studies proved that crossing nerve transfer surgery could rebuild physiological connectivity between the contralesional cortex and the paralyzed arm to compensate for the lost function after brain injury. However, the neural mechanism by which this surgery mediates motor recovery remains still unclear. Here, using a clinical mouse model, we showed that this surgery can restore skilled forelimb function in adult mice with unilateral cortical lesion by inducing cortical remapping and promoting corticospinal tract sprouting. After reestablishing the ipsilateral descending pathway, resecting of the artificially rebuilt peripheral nerve did not affect motor improvements. Furthermore, retaining the sensory afferent, but not the motor efferent, of the transferred nerve was sufficient for inducing brain remapping and facilitating motor restoration. Thus, our results demonstrate that surgically rebuilt sensory input triggers neural plasticity for accelerating motor recovery, which provides an approach for treating central nervous system injuries. Reconstructing sensory input was vital to induce intrinsic neural plasticity to restore skilled motor function after brain injury.
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DOI：
10.1073/pnas.1716470115
发表时间：
2018-09-04
影响因子：
11.1
作者：
Chuang YC;Lee CH;Sun WH;Chen CC
通讯作者：
Chen CC
影响因子：
3.5
作者：
Hira R;Ohkubo F;Tanaka YR;Masamizu Y;Augustine GJ;Kasai H;Matsuzaki M
通讯作者：
Matsuzaki M
影响因子：
4.6
作者：
Bankhead P;Loughrey MB;Fernández JA;Dombrowski Y;McArt DG;Dunne PD;McQuaid S;Gray RT;Murray LJ;Coleman HG;James JA;Salto-Tellez M;Hamilton PW
通讯作者：
Hamilton PW
影响因子：
25
作者：
Cai, Ruiyao;Pan, Chenchen;Ertuerk, Ali
通讯作者：
Ertuerk, Ali
DOI：
10.1073/pnas.1316885110
发表时间：
2013-12-24
影响因子：
11.1
作者：
Guggenmos, David J.;Azin, Meysam;Nudo, Randolph J.
通讯作者：
Nudo, Randolph J.