Ethanol modulation of cortico-basolateral amygdala circuits: Neurophysiology and behavior.

Ethanol modulation of cortico-basolateral amygdala circuits: Neurophysiology and behavior.
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DOI:
10.1016/j.neuropharm.2021.108750
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发表时间:
2021-10-01
期刊:
影响因子:
4.7
通讯作者:
McCool BA
McCool BA
中科院分区:
医学2区
文献类型:
--
作者:
McCool BA

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This review highlights literature relating the anatomy, physiology, and behavioral contributions by projections between rodent prefrontal cortical areas and the basolateral amygdala. These projections are robustly modulated by both environmental experience and exposure to drugs of abuse including ethanol. Recent literature relating optogenetic and chemogenetic dissection of these circuits within behavior both compliments and occasionally challenges roles defined by more traditional pharmacological or lesion-based approaches. In particular, cortico-amygdala circuits help control both aversive and reward-seeking. Exposure to pathology-producing environments or abused drugs dysregulates the relative ‘balance’ of these outcomes. Modern circuit-based approaches have also shown that overlapping populations of neurons within a given brain region frequently govern both aversion and reward-seeking. In addition, these circuits often dramatically influence ‘local’ cortical or basolateral amygdala excitatory or inhibitory circuits. Our understanding of these neurobiological processes, particularly in relation to ethanol research, has just begun and represents a significant opportunity.
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