Nuclear receptor coactivators: master regulators of human health and disease.
Nuclear receptor coactivators: master regulators of human health and disease.
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DOI：
10.1146/annurev-med-051812-145316
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发表时间：
2014
影响因子：
10.5
通讯作者：
O'Malley BW
中科院分区：
文献类型：
--
作者：
Dasgupta S;Lonard DM;O'Malley BW
转录辅调节因子（辅激活因子和辅阻遏因子）已成为核受体和其他转录因子功能的主要调节因子。自第一个真正的核心调节因子类固醇受体辅激活因子-1 (SRC-1) 发现以来的十年间，已鉴定和表征了 400 多个核心调节因子，破译它们的功能对我们了解它们在人类生理学中的作用做出了重大贡献。核心调节因子的表达失调与多种疾病状态和相关病理有关。分子技术的进步使我们能够在基因调控的背景下更好地表征 SRC 共激活剂家族与其他蛋白质复合物的分子关联。这些持续的发现不仅扩大了我们对共激活剂在各种人类疾病中的作用的认识，而且使我们能够发现新的共激活剂靶向策略来治疗干预这些疾病。
Transcriptional coregulators (coactivators and corepressors) have emerged as the principal modulators of the functions of nuclear receptors and other transcription factors. During the decade since the discovery of steroid receptor coactivator-1 (SRC-1), the first authentic coregulator, more than 400 coregulators have been identified and characterized, and deciphering their function has contributed significantly to our understanding of their role in human physiology. Deregulated expression of coregulators has been implicated in diverse disease states and related pathologies. The advancement of molecular technologies has enabled us to better characterize the molecular associations of the SRC family of coactivators with other protein complexes in the context of gene regulation. These continuing discoveries not only expand our knowledge of the roles of coactivators in various human diseases but allow us to discover novel coactivator-targeting strategies for therapeutic intervention in these diseases.
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DOI：
10.1073/pnas.0808207105
发表时间：
2008-11-04
影响因子：
11.1
作者：
Coste, Agnes;Louet, Jean-Francois;Auwerx, Johan
通讯作者：
Auwerx, Johan
影响因子：
11.2
作者：
Cai D;Shames DS;Raso MG;Xie Y;Kim YH;Pollack JR;Girard L;Sullivan JP;Gao B;Peyton M;Nanjundan M;Byers L;Heymach J;Mills G;Gazdar AF;Wistuba I;Kodadek T;Minna JD
通讯作者：
Minna JD
影响因子：
10.9
作者：
Han, Sang Jun;Lonard, David M.;O'Malley, Bert W.
通讯作者：
O'Malley, Bert W.
影响因子：
--
作者：
Han, SJ;DeMayo, FJ;O'Malley, BW
通讯作者：
O'Malley, BW
影响因子：
--
作者：
Dasgupta S;Srinidhi S;Vishwanatha JK
通讯作者：
Vishwanatha JK